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1. |
Record Nr. |
UNINA9910253903303321 |
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Titolo |
The Next Generation in Membrane Protein Structure Determination / / edited by Isabel Moraes |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
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ISBN |
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Edizione |
[1st ed. 2016.] |
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Descrizione fisica |
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1 online resource (187 p.) |
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Collana |
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Advances in Experimental Medicine and Biology, , 0065-2598 ; ; 922 |
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Disciplina |
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Soggetti |
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Proteins |
Protein Science |
Protein Structure |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Expression Screening of Integral Membrane Proteins by Fusion to Fluorescent Reporters -- Detergents in Membrane Protein Purification and Crystallisation -- NMR of Membrane Proteins: Beyond Crystals -- Characterisation of Conformational and Ligand Binding Properties of Membrane Proteins Using Synchrotron Radiation Circular Dichroism (SRCD) -- Membrane Protein Crystallization: Current Trends and Future Perspectives -- Crystal Dehydration in Membrane Protein Crystallography -- Nonlinear Optical Characterization of Membrane Protein Microcrystals and Nanocrystals -- Exploiting Microbeams for Membrane Protein Structure Determination -- Applications of the BLEND Software to Crystallographic Data from Membrane Proteins -- Serial Millisecond Crystallography of Membrane Proteins -- Serial Femtosecond Crystallography of Membrane Proteins -- Beyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties. |
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Sommario/riassunto |
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This book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects. Today, about 60% of the commercially available drugs target membrane proteins and it is |
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estimated that nearly 30% of proteins encoded in the human genome are membrane proteins. In recent years much effort has been put towards innovative developments to overcome the numerous obstacles associated with the structure determination of membrane proteins. This book reviews a variety of recent techniques that are essential to any modern researcher in the field of membrane protein structural biology. The topics that are discussed are not commonly found in textbooks. The scope of this book includes: Expression screening using fluorescent proteins The use of detergents in membrane protein research The use of NMR Synchrotron developments in membrane protein structural biology Visualisation and X-ray data collection of microcrystals X-ray diffraction data analysis from multiple crystals Serial millisecond crystallography Serial femtosecond crystallography Membrane protein structures in drug discovery The information provided in this book should be of interest to anyone working in the area of structural biology. Students will find carefully prepared overviews of basic ideas and advanced protein scientists will find the level of detail required to apply the material directly to their day to day work. |
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2. |
Record Nr. |
UNINA9910483647003321 |
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Titolo |
Architecture of Computing Systems - ARCS 2008 : 21st International Conference, Dresden, Germany, February 25-28, 2008, Proceedings / / edited by Theo Ungerer, Christian Hochberger, Rainer G. Spallek |
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Pubbl/distr/stampa |
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Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2008 |
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ISBN |
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Edizione |
[1st ed. 2008.] |
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Descrizione fisica |
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1 online resource (XI, 290 p.) |
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Collana |
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Theoretical Computer Science and General Issues, , 2512-2029 ; ; 4934 |
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Disciplina |
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Soggetti |
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Computer science |
Computer networks |
Computer systems |
Operating systems (Computers) |
Software engineering |
Application software |
Theory of Computation |
Computer Communication Networks |
Computer System Implementation |
Operating Systems |
Software Engineering |
Computer and Information Systems Applications |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di contenuto |
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Invited Program -- Keynote: Grand Challenges of Computer Engineering -- Keynote: The Impact of Operating Systems on Modern CPU Designs (and Vice Versa) -- I Hardware Design -- System Level Simulation of Autonomic SoCs with TAPES -- Topology-Aware Replica Placement in Fault-Tolerant Embedded Networks -- Design of Gate Array Circuits Using Evolutionary Algorithms -- II Pervasive Computing -- Direct Backtracking: An Advanced Adaptation Algorithm for Pervasive Applications -- Intelligent Vehicle Handling: Steering and Body Postures While Cornering -- III Network Processors and Memory |
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Management -- A Hardware Packet Re-Sequencer Unit for Network Processors -- Self-aware Memory: Managing Distributed Memory in an Autonomous Multi-master Environment -- IV Reconfigurable Hardware -- Dynamic Reconfiguration of FlexRay Schedules for Response Time Reduction in Asynchronous Fault-Tolerant Networks -- Synthesis of Multi-dimensional High-Speed FIFOs for Out-of-Order Communication -- A Novel Routing Architecture for Field-Programmable Gate-Arrays -- V Real-Time Architectures -- A Predictable Simultaneous Multithreading Scheme for Hard Real-Time -- Soft Real-Time Scheduling on SMT Processors with Explicit Resource Allocation -- A Hardware/Software Codesign of a Co-processor for Real-Time Hyperelliptic Curve Cryptography on a Spartan3 FPGA -- VI Organic Computing -- A Reference Architecture for Self-organizing Service-Oriented Computing -- Towards Self-organising Smart Camera Systems -- Using Organic Computing to Control Bunching Effects -- VII Computer Architecture -- A Generic Network Interface Architecture for a Networked Processor Array (NePA) -- Constructing Optimal XOR-Functions to Minimize Cache Conflict Misses -- Potentials of Branch Predictors: From Entropy Viewpoints. |
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Sommario/riassunto |
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This book constitutes the refereed proceedings of the 21st International Conference on Architecture of Computing Systems, ARCS 2008, held in Dresden, Germany, in February 2008. The 19 revised full papers presented together with 2 keynote papers were carefully reviewed and selected from 47 submissions. The papers cover a wide spectrum reaching from pre-fabrication adaptation of architectural templates to dynamic run-time adaptation of deployed systems with special focus on adaptivity and adaptive system architectures. The papers are organized in topical sections on hardware design, pervasive computing, network processors and memory management, reconfigurable hardware, real-time architectures, organic computing, and computer architecture. |
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