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1. |
Record Nr. |
UNINA9910253880103321 |
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Titolo |
B Cell Receptor Signaling / / edited by Tomohiro Kurosaki, Jürgen Wienands |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
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ISBN |
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Edizione |
[1st ed. 2016.] |
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Descrizione fisica |
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1 online resource (231 p.) |
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Collana |
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Current Topics in Microbiology and Immunology, , 2196-9965 ; ; 393 |
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Disciplina |
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Soggetti |
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Immunology |
Medicine - Research |
Biology - Research |
Cancer |
Biomedical Research |
Cancer Biology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters. |
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Nota di contenuto |
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Assembly and function of the precursor B-cell receptor -- Receptor Dissociation and B cell activation -- Molecular mechanisms of B cell antigen gathering and endocytosis -- BTK signaling in B cell differentiation and autoimmunity -- The memory function of the B cell antigen receptor -- PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL) -- Role of Calcium Signaling in B Cell Activation and Biolog -- Roles of the NF-kappaB pathway in B-lymphocyte biology -- MAP kinase cascades in antigen receptor signaling and physiology. |
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Sommario/riassunto |
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This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These |
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elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases. |
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2. |
Record Nr. |
UNINA9910488701103321 |
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Titolo |
Advances in Thermal Engineering, Manufacturing, and Production Management : Select Proceedings of ICTEMA 2020 / / edited by Sadhan Kumar Ghosh, Koushik Ghosh, Santanu Das, Pranab Kumar Dan, Arijit Kundu |
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Pubbl/distr/stampa |
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Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2021 |
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ISBN |
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Edizione |
[1st ed. 2021.] |
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Descrizione fisica |
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1 online resource (xvii, 404 pages) : illustrations (some color) |
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Collana |
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Lecture Notes in Mechanical Engineering, , 2195-4364 |
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Disciplina |
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Soggetti |
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Thermodynamics |
Heat engineering |
Heat transfer |
Mass transfer |
Manufactures |
Security systems |
Business logistics |
Industrial Management |
Engineering Thermodynamics, Heat and Mass Transfer |
Machines, Tools, Processes |
Security Science and Technology |
Supply Chain Management |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Numerical Analysis of Heat Transfer Characteristics Under Single-Jet Air Impingement -- Numerical Analysis of Micro-Scale Diffusion Flame Structure Using Methane Gas as Fuel -- Magneto-convective Heat Transfer in a Cavity Under Partial Magnetic Fields -- A Proposal for Harnessing an Alternative Source of Renewable Energy. |
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Sommario/riassunto |
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This book presents the selected peer-reviewed proceedings of the International Conference on Thermal Engineering and Management Advances (ICTEMA 2020). The contents discuss latest research in the areas of thermal engineering, manufacturing engineering, and production management. Some of the topics covered include multiphase fluid flow, turbulent flows, reactive flows, atmospheric flows, combustion and propulsion, computational methods for thermo-fluid arena, micro and nanofluidics, renewable energy and environment sustainability, non-conventional energy resources, energy principles and management, machine dynamics and manufacturing, casting and forming, green manufacturing, production planning and management, quality control and management, and traditional and non-traditional manufacturing. The contents of this book will be useful for students, researchers as well as professionals working in the area of mechanical engineering and allied fields. |
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