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1. |
Record Nr. |
UNISALENTO991002020129707536 |
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Autore |
Murray, William D. |
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Titolo |
Paper folding for beginners / by William D. Murray and Francis J. Rigney |
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Descrizione fisica |
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Classificazione |
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Altri autori (Persone) |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Formerly titled: Fun with paper folding." |
Ex Libris Mario Lombardo |
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2. |
Record Nr. |
UNINA9910227350203321 |
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Autore |
Amadou K. S. Camara |
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Titolo |
Mitochondria: Hubs of Cellular Signaling, Energetics and Redox Balance |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (228 p.) |
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Collana |
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Frontiers Research Topics |
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Lingua di pubblicazione |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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Poised at the convergence of most catabolic and anabolic pathways, mitochondria are the center of heterotrophic aerobic life, representing a hub in the overall metabolic network of cells. The energetic functions performed by mitochondria face the unavoidable redox hurdle of handling huge amounts of oxygen while keeping its own as well as the cellular redox environment under control. Reactive oxygen species (ROS) are produced in the respiratory chain as a result of the energy supplying function of mitochondria. Originally considered an unavoidable by-product of oxidative phosphorylation, ROS have become crucial signaling molecules when their levels are kept within physiological range. This occurs when their production and scavenging are balanced within mitochondria and cells. Mitochondria-generated hydrogen peroxide can act as a signaling molecule within mitochondria or in the cytoplasm, affecting multiple networks that control, for example, cell cycle, stress response, cell migration and adhesion, energy metabolism, redox balance, cell contraction, and ion channels. However, under pathophysiological conditions, excessive ROS levels can happen due to either overproduction, overwhelming of antioxidant defenses, or both. Under oxidative stress, detrimental effects of ROS include oxidation of protein, lipids, and nucleic acids; mitochondrial depolarization and calcium overload; and cell-wide oscillations mediated by ROS-induced ROS release mechanisms. Mitochondrial dysfunction is central in the pathogenesis of numerous human |
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maladies including cardiomyopathies and neurodegeneration. Diseases characterized by altered nutrient metabolism, such as diabetes and cancer, exhibit elevated ROS levels. These may contribute to pathogenesis by increasing DNA mutation, affecting regulatory signaling and transcription, and promoting inflammation. Under metabolic stress, several ionic channels present in the inner and outer mitochondrial membranes can have pro-life and -death effects. In the present E-book, based on the Frontiers Research Topic entitled: "Mitochondria: Hubs of cellular signaling, energetics and redox balance", we address one of the fundamental questions that the field of ROS biology faces today: how do mitochondria accomplish a reliable energy provision and at the same time keep ROS levels within physiological, non-harming, limits but crucial for cellular signaling function? Additionally, and within the perspective of mitochondria as signaling-energetic hubs in the extensive cellular metabolic network, we ask how can their collective dynamics scale from the subcellular to the cellular, tissue and organ levels to affect function in health and disease. |
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3. |
Record Nr. |
UNINA9910557544203321 |
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Autore |
Román Tomás Gómez San |
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Titolo |
Integration of Renewable and Distributed Energy Resources in Power Systems |
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Pubbl/distr/stampa |
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Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
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Descrizione fisica |
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1 online resource (228 p.) |
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Soggetti |
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History of engineering and technology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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The electric power sector is poised for transformative changes. Improvements in the cost and performance of a range of distributed |
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energy generation (DG) technologies and the potential for breakthroughs in distributed energy storage (DS) are creating new options for onsite power generation and storage, driving increasing adoption and impacting utility distribution system operations. In addition, changing uses and use patterns for electricity-from plug-in electric vehicles (EVs) to demand response (DR)-are altering demands placed on the electric power system. Finally, the infusion of new information and communications technology (ICT) into the electric system and its markets is enabling the collection of immense volumes of data on power sector operations and use; unprecedented control of generation, networks, and loads; and new opportunities for the delivery of energy services. In this Special Issue of Energies, research papers on topics related to the integration of distributed energy resources (DG, DS, EV, and DR) are included. From technologies to software tools to system-wide evaluations, the impacts of all aforementioned distributed resources on both operation and planning are examined. |
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