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1. |
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UNINA9910159442203321 |
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Autore |
Melville Herman |
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Titolo |
Moby Dick / / Herman Melville |
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Pubbl/distr/stampa |
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New York, New York : , : Race Point Publishing, , 2016 |
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©2016 |
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ISBN |
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Descrizione fisica |
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1 online resource (507 pages) |
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Disciplina |
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Soggetti |
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Ahab, Captain (Fictitious character) |
Children's plays, American |
Whaling |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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2. |
Record Nr. |
UNINA9910404073803321 |
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Autore |
Dose Nicolai |
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Titolo |
Kleinstaaterei im Dienstrecht der deutschen Bundesländer : Probleme bei der Bundesländergrenzen überschreitenden Mobilität von Landesbeamten nach der Föderalismusreform I |
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Pubbl/distr/stampa |
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Nomos Verlagsgesellschaft mbH & Co. KG, 2020 |
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Descrizione fisica |
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1 electronic resource (107 p.) |
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Collana |
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Modernisierung des öffentlichen Sektors ( |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Mit der Föderalismusreform 2006 sind den Ländern Gesetzgebungskompetenzen zur Regelung des Beamtenbereichs zugewachsen. Dies hat nicht nur zu deutlich unterschiedlichen Besoldungshöhen in den Ländern geführt, sondern auch zu einem fragmentierten und unterschiedlich attraktiven Dienstrecht. Wechselwünsche treffen in den verschiedenen Bereichen des öffentlichen Dienstes auf unterschiedliche Schwierigkeiten, die zum Teil auf das fragmentierte Dienstrecht und zum Teil auf informelle Absprachen zwischen den Ländern zurückzuführen sind. Durch eine Online-Umfrage bei Personalverantwortlichen der öffentlichen Verwaltung und durch 32 Fallstudien von angestrebten Bundeslandwechseln betroffener Beamter werden Motivationen und Mobilitätshindernisse systematisch erhoben und analysiert. Dabei wurden sowohl hinderliche, als auch förderliche Faktoren für die Mobilität von Beamten identifiziert. Die Autoren entwickeln zudem eine Reihe von Reformvorschlägen zum Abbau von Mobilitätshindernissen. With the federalism reform of 2006, the German federal states gained legislative power over their civil servants. This did not only lead to a substantial difference in pay levels but also to fragmented civil service regulations with different degrees of attractiveness. Requests to move to another state have created various problems in the different areas of the civil service. They are partly caused by the fragmented regulations |
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and partly by an informal agreement between the states. By making use of an online survey among human resource managers in the different areas of public administration and 32 case studies of civil servants who either aspire to move to or have moved to another state, this book systematically identifies and analyses civil servants’ motivations for and hindrances to doing so. In this way, it reveals both obstructive and conducive factors which explain mobility. Moreover, the authors put forward some reform proposals. |
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3. |
Record Nr. |
UNINA9910220040303321 |
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Autore |
Irving E. Vega |
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Titolo |
Unraveling Neuroprotective and Neurodegenerative Signals in Neurodegeneration |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (131 p.) |
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Collana |
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Frontiers Research Topics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Proteinopathy is a collective term used to classified neurodegenerative diseases associated with the progressive accumulation of toxic protein molecules in specific brain regions. Alzheimer's disease (AD) is a well-known proteinopathy characterize by the accumulation of A peptides and tau proteins. The accumulation of these toxic molecules in the brain starts many years before any clinical presentation, being the onset in the range of 65 to 72 years of age. Therefore, age is considered a risk factor due, in part, to the loss of molecular competence to clear the brain from these toxic protein molecules. This fact, supported by years of research, demonstrates that brain cells activate a neuroprotective mechanism upon detection of a pathobiological signal that (if the detrimental conditions persist) precedes the activation of the neurodegeneration pathway. The |
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progressive brain region specific neuronal death in neurodegenerative diseases also indicates that the transition from neuroprotection to neurodegeneration is individually triggered in cells of the affected brain region. Thus, molecular understanding of the pathophysiology associated with proteinopathies needs to take in consideration this intricate transition process, especially when genomics and proteomics approaches are used. Research directed to understand the pathogenesis and pathophysiology of neurodegenerative diseases uncovered the putative role of different molecular mechanisms associated with neurodegeneration. Among the molecular mechanisms identified are proteolysis, epigenetics, microRNA, transcriptional regulation, innate and adaptive immune system, phagocytosis and autophagocytosis, exo/endocytosis, unfolded protein response, cytoskeleton defects, unregulated signaling molecules (i.e. kinases and phosphatases), trafficking molecules, cell cycle, neurogenesis/neurodevelopment, among others. Interestingly, all these molecular mechanisms have been identified through the analysis of tissue from animal models or human post-mortem pathologically confirmed cases, but their specific role in neurodegeneration is still unclear. Thus, it is plausible to consider that all these pathways play a role at a particular phase of the neurodegeneration process or, simply, are drive by the agonal state of the tissue examined. Hence, an important conundrum that researchers face today is the use of heterogeneous brain tissue samples in the quest to identify biomarkers associated with the pathogenesis or pathophysiology of neurodegenerative diseases. At this junction of the neurodegeneration field, this research topic aim to critically assess the current literature on molecular mechanisms associated with neurodegeneration and the approaches used to dissect their putative pathophysiological role. The studies could include the interplay between neuroprotective and neurodegenerative signals in neurodegeneration, dissecting the molecular role of identified biomarkers, bioinformatics tools that facilitate data mining, dissecting pathways or molecular mechanisms, stages of protein aggregation (oligomers vs tangles; who did it?), aging brain and brain fitness (A natural selection process), adaptive protein response to environmental insults and cellular signals, expression profile associated with neurological disorders and health. Therefore, this Research Topic is expected to cover a wide range of subjects related to unravel the interplay between neuroprotective and neurodegenerative signals in neurodegeneration. |
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