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1. |
Record Nr. |
UNINA9910213853903321 |
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Autore |
Stroh Silke |
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Titolo |
Gaelic Scotland in the Colonial Imagination [[electronic resource] ] : Anglophone Writing from 1600 to 1900 / / Silke Stroh |
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Pubbl/distr/stampa |
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Evanston, Illinois : , : Northwestern University Press, , 2017 |
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©2017 |
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ISBN |
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Descrizione fisica |
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1 online resource (340 pages) |
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Disciplina |
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Soggetti |
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Postcolonialism in literature |
Celts in literature |
Scottish literature - 19th century - History and criticism |
Scottish literature - 18th century - History and criticism |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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The modern nation-state and its others: civilizing missions at home and abroad, ca. 1600 to 1800 -- Anglophone literature of civilization and the hybridized Gaelic subject: Martin Martin's travel writings -- The reemergence of the primitive other? Noble savagery and the romantic age -- From flirtations with romantic otherness to a more integrated national synthesis: "Gentleman savages" in Walter Scott's novel Waverley -- Of Celts and Teutons: racial biology and anti-Gaelic discourse, ca. 1780-1860 -- Racist reversals: Appropriating racial typology in late-nineteenth-century pro-Gaelic discourse. |
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Sommario/riassunto |
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Can Scotland be considered an English colony? Is its experience and literature comparable to that of overseas postcolonial countries? Or are such comparisons no more than victimology to mask Scottish complicity in the British Empire and justify nationalism? These questions have been heatedly debated in the aftermath of the 2014 referendum on independence and amid a continuing campaign for more autonomy. Gaelic Scotland in the Colonial Imagination offers an introduction to the emerging field of postcolonial Scottish studies, assessing both its potential and limitations to promote further interdisciplinary dialogue. Accessible to readers from various |
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backgrounds, the book combines overviews of theoretical, social, and cultural contexts with detailed case studies of literary and nonliterary texts. Silke Stroh shows how the image of Scotland's Gaelic margins changed under the influence of the emergence of the modern nation-state and the rise of overseas colonialism. |
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2. |
Record Nr. |
UNINA9910787961903321 |
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Titolo |
Clinical trial biostatistics and biopharmaceutical applications / / editors, Walter R. Young, Ding-Geng (Din) Chen |
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Pubbl/distr/stampa |
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Boca Raton : , : CRC Press, , [2015] |
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©2015 |
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ISBN |
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0-429-17306-7 |
1-4822-1219-6 |
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Descrizione fisica |
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1 online resource (574 p.) |
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Disciplina |
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Soggetti |
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Medicine - Research - Statistical methods |
Clinical trials - Methodology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Front Cover; Contents; List of Figures; List of Tables; Preface; Early History of the DemingConference; Some Nonstatistical Reminiscences of My 44 Years of Chairing the Deming Conference; Contributors; Section I: Emerging Issues in ClinicalTrial Design and Analysis; Chapter 1: Emerging Challenges of Clinical Trial Methodologies in Regulatory Applications; Chapter 2: Review of Randomization Methodsin Clinical Trials; Chapter 3: First Dose Ranging Clinical Trial Design:More Doses? Or aWider Range?; Chapter 4: Thorough QT/QTc Clinical Trials |
Chapter 5: Controversial (Unresolved) Issues in Noninferiority TrialsSection II: Adaptive Clinical Trials; Chapter 6: Adaptive Designs in Drug Development; Chapter 7: Optimizing Group-Sequential Designs with Focus on Adaptability: Implications of Nonproportional Hazards in Clinical Trials; Chapter 8: Group Sequential Design in R; Section III: Clinical Trials in Oncology; Chapter 9: Issues in the Design and Analysis |
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of Oncology Clinical Trials; Chapter 10: Competing Risks and Their Applications in Cancer Clinical Trials |
Chapter 11: Dose Finding with Escalation with Overdose Control in Cancer Clinical TrialsChapter 12: Interval-Censored Time-to-Event Data andT heir Applications in Clinical Trials; Section IV: Multiple Comparisons in Clinical Trials; Chapter 13: Introduction to Multiple Test Problems, with Applications to Adaptive Designs; Chapter 14: Graphical Approaches to Multiple Testing; Chapter 15: Pairwise Comparisons with Binary Responses: Multiplicity-Adjusted P-Values and Simultaneous Confidence Intervals |
Chapter 16: Comparative Study of Five Weighted Parametric Multiple Testing Methods for Correlated Multiple Endpoints in Clinical TrialsSection V: Clinical Trials in a Genomic Era; Chapter 17: Statistical Analysis of Biomarkers from -Omics Technologies; Chapter 18: Understanding Therapeutic Pathways via Biomarkers and Other Uses of Biomarkers in Clinical Studies; Chapter 19: Statistical Evaluation of Surrogate Endpoints in Clinical Studies; Back Cover |
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Sommario/riassunto |
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Since 1945, The Annual Deming Conference on Applied Statistics has been an important event in the statistics profession. In Clinical Trial Biostatistics and Biopharmaceutical Applications, prominent speakers from past Deming conferences present novel biostatistical methodologies in clinical trials as well as up-to-date biostatistical applications from the pharmaceutical industry. Divided into five sections, the book begins with emerging issues in clinical trial design and analysis, including the roles of modeling and simulation, the pros and cons of randomization procedures, the design of Phase II dose-ranging trials, thorough QT/QTc clinical trials, and assay sensitivity and the constancy assumption in noninferiority trials. The second section examines adaptive designs in drug development, discusses the consequences of group-sequential and adaptive designs, and illustrates group sequential design in R. The third section focuses on oncology clinical trials, covering competing risks, escalation with overdose control (EWOC) dose finding, and interval-censored time-to-event data. In the fourth section, the book describes multiple test problems with applications to adaptive designs, graphical approaches to multiple testing, the estimation of simultaneous confidence intervals for multiple comparisons, and weighted parametric multiple testing methods. The final section discusses the statistical analysis of biomarkers from omics technologies, biomarker strategies applicable to clinical development, and the statistical evaluation of surrogate endpoints.This book clarifies important issues when designing and analyzing clinical trials, including several misunderstood and unresolved challenges. It will help readers choose the right method for their biostatistical application. Each chapter is self-contained with references--Provided by publisher. |
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