1.

Record Nr.

UNINA9910209659103321

Titolo

Convergence and system change : the convergence hypothesis in the light of transition in Eastern Europe / edited by Bruno Dallago, Horst Brezinski, Wladimir Andreff

Pubbl/distr/stampa

Aldershot \etc.! : Dartmouth, 1992

ISBN

1855212188

Descrizione fisica

XII, 255 p. ; 23 cm

Disciplina

330.91717

Locazione

DECTS

Collocazione

ISVE P01.19

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

2.

Record Nr.

UNINA9910585937103321

Autore

Allgayer Heike

Titolo

Colorectal Cancers: From Present Problems to Future Solutions

Pubbl/distr/stampa

Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022

Descrizione fisica

1 electronic resource (238 p.)

Soggetti

Medicine

Oncology

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Sommario/riassunto

The scientific community has made significant progress in our molecular understanding of sporadic and hereditary colorectal



carcinogenesis and progression. Thie pertains to, e.g., the discovery of (mutated) oncogenes and tumor suppressor genes, microsatellite instabilities, modifications in DNA repair, cellular aging, signaling cascades, genomic, epigenetic, transcriptional, translational, and protein modifications, as well as microbiotic factors and further parameters. Progression and metastasis have been more intensively studied, especially during recent years, leading to an intensified knowledge on molecular protagonists and microenvironmental interactions contributing to invasion, dissemination, and metastasis; still, more concerted efforts need to be made to better understand issues such as metastasis to different sites or the metastatic heterogeneity of single cells. Nevertheless, based on actual discoveries, personalized medicine, together with highly interdisciplinary therapeutic strategies combining advanced levels of surgical techniques, oncology, and radiation in neoadjuvant, adjuvant, or palliative settings, has started to improve the clinical prognosis of individual patients with colorectal cancer. The present Special Issue features articles of excellent international experts with the latest data in the fields mentioned. With this Special Issue, we aim to deepen discussions amongst colleagues in all kinds of disciplines working on this disease and to intensify interdisciplinary collaborations aimed at an ultimate understanding of strategies to defeat and prevent, colorectal cancer, and its progression.