| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910163124703321 |
|
|
Autore |
Matzat Lorenz |
|
|
Titolo |
Datenjournalismus : Methode einer digitalen Welt / / Lorenz Matzat |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Köln, : Herbert von Halem Verlag, 2016 |
|
|
|
|
|
|
|
ISBN |
|
3-7445-1049-2 |
3-86496-988-3 |
|
|
|
|
|
|
|
|
Edizione |
[1st ed.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (107 pages) : illustrations (some color), graphs |
|
|
|
|
|
|
Collana |
|
Praktischer Journalismus ; 101 |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Berichterstattung |
Datenanalyse |
Datenjournalismus |
Datenvisualisierung |
Digitalisierung |
Journalismus |
data-driven-journalism |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
|
|
|
|
|
Sommario/riassunto |
|
Datenjournalismus ist eine Reaktion auf die anhaltende Digitalisierung. Er ist eng mit Software und Algorithmen verknüpft, nährt sich vom gleichen Treibstoff wie die Rechner und das Internet: Daten. Welche Methode wäre also besser dafür geeignet, eine digitale Welt zu begleiten und zu beschreiben? Der Datenjournalist Lorenz Matzat gibt einen Einblick in das recht junge Genre Datenjournalismus und richtet sich damit an Einsteiger in das Thema: Was gehört zum sogenannten data-driven-journalism und wie lässt er sich umSetzen? Im ersten Kapitel geht es um den Rohstoff des Ganzen: Daten und deren Formate - wie im Zusammenspiel mit Software interaktiver Journalismus gemacht kann. Der zweite Abschnitt dreht sich um das methodische Vorgehen: Dem Beschaffen und Säubern von Daten, der Analyse der Daten und der Berichterstattung mit ihnen. Der dritte und letzte Abschnitt handelt von dem Produkt, dem journalistischen Werk: Es ist dabei nicht nur die Rede vom prägnanten Journalismus, sondern auch |
|
|
|
|
|
|
|
|
|
|
|
|
|
von Servertechnologie, Nutzerfreundlichkeit, Testen und nicht zuletzt von Datenvisualisierungen. Dieses Buch verspricht weder, aus dem Leser in Nullkommanichts einen Könner im Datenjournalismus zu machen. Auch fordert es nicht, dass jeder Journalist Programmierer werden sollte. Vielmehr zeigt Lorenz Matzat, dass Datenjournalismus viel Arbeit, Geduld und Teamarbeit verlangt. Aber auch, dass diese Arbeit entsprechend belohnt wird: und zwar mit der Möglichkeit, aussagekräftig und vielfältig das digitale Medium Internet bespielen zu können. www.datenjournalist.de/buch |
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910137089403321 |
|
|
Autore |
Jorg Stulke |
|
|
Titolo |
Regulatory potential of post-translational modifications in bacteria |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (204 p.) |
|
|
|
|
|
|
Collana |
|
Frontiers Research Topics |
|
|
|
|
|
|
Soggetti |
|
Microbiology (non-medical) |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Sommario/riassunto |
|
Post-translational modifications (PTMs) are widely employed by all living organisms to control the enzymatic activity, localization or stability of proteins on a much shorter time scale than the transcriptional control. In eukarya, global analyses consistently reveal that proteins are very extensively phosphorylated, acetylated and ubiquitylated. Glycosylation and methylation are also very common, and myriad other PTMs, most with a proven regulatory potential, are being discovered continuously. The emergent picture is that PTM sites on a single protein are not independent; modification of one residue often affects (positively or negatively) modification of other sites on the same protein. The best example of this complex behavior is the histone "bar-code" with very extensive cross-talk between phosphorylation, |
|
|
|
|
|
|
|
|
|
|
acetylation and methylation sites. Traditionally it was believed that large networks of PTMs exist only in complex eukaryal cells, which exploit them for coordination and fine-tuning of various cellular functions. PTMs have also been detected in bacteria, but the early examples focused on a few important regulatory events, based mainly on protein phosphorylation. The global importance (and abundance) of PTMs in bacterial physiology was systematically underestimated. In recent years, global studies have reported large datasets of phosphorylated, acetylated and glycosylated proteins in bacteria. Other modifications of bacterial proteins have been recently described: pupylation, methylation, sirtuin acetylation, lipidation, carboxylation and bacillithiolation. As the landscape of PTMs in bacterial cells is rapidly expanding, primarily due to advances of detection methods in mass spectrometry, our research field is adapting to comprehend the potential impact of these modifications on the cellular physiology. The field of protein phosphorylation, especially of the Ser/Thr/Tyr type, has been profoundly transformed. We have become aware that bacterial kinases phosphorylate many protein substrates and thus constitute regulatory nodes with potential for signal integration. They also engage in cross-talk and eukaryal-like mutual activation cascades. The regulatory potential of protein acetylation and glycosylation in bacteria is also rapidly emerging, and the cross-talk between acetylation and phosphorylation has been documented. This topic deals with the complexity of the PTM landscape in bacteria, and focus in particular on the physiological roles that PTMs play and methods to study them. The topic is associated to the 1st International Conference on Post-Translational Modifications in Bacteria (September 9-10, 2014, Göttingen, Germany). |
|
|
|
|
|
| |