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UNINA9910826657303321 |
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Autore |
Ramin Brodie <1982-> |
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Titolo |
The age of fentanyl : ending the opioid epidemic / / Brodie Ramin |
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Pubbl/distr/stampa |
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Toronto, Ontario : , : Dundurn, , [2020] |
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©2020 |
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Descrizione fisica |
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1 online resource (236 pages) |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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"Is there a way to end North America's opioid epidemic? North America is facing a crisis. The first warning signs appeared in media reports of OxyContin abuse and over-prescription in the 1990s. Today, there is an opioid epidemic -- fentanyl is the leading cause of overdose death in North America. From his perspective as an addiction physician working on the front lines of the epidemic, Dr. Brodie Ramin discusses the disease and the cure. Looking beyond the obstacles, The Age of Fentanyl brings the hopeful message that just as patients and health care workers rallied together to fight the HIV epidemic one generation ago, a coalition of patients, advocates, scientists, doctors, and nurses are finding solutions and making plans to stem the overdose deaths, block the spread of fentanyl, and end the epidemic."-- |
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2. |
Record Nr. |
UNINA9910161648603321 |
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Autore |
Loreto Holuigue |
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Titolo |
Salicylic Acid Signaling Networks |
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Descrizione fisica |
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1 online resource (188 p.) |
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Collana |
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Frontiers Research Topics |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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The small phenolic compound salicylic acid (SA) is critical for plant defense against a broad spectrum of pathogens. SA is also involved in multi-layered defense responses, from pathogen-associated molecular pattern triggered basal defense, resistance gene-mediated defense, to systemic acquired resistance. Recent decades have witnessed tremendous progress towards our understanding of SA-mediated signaling networks. Many genes have been identified to have direct or indirect effect on SA biosynthesis or to regulate SA accumulation. Several SA receptors have been identified and characterization of these receptors has shed light on the mechanisms of SA-mediated defense signaling, which encompass chromosomal remodeling, DNA repair, epigenetics, to transcriptional reprogramming. Molecules from plant-associated microbes have been identified, which manipulate SA levels and/or SA signaling. SA does not act alone. It engages in crosstalk with other signaling pathways, such as those mediated by other phytohormones, in an agonistic or antagonistic manner, depending on hormones and pathosystems. Besides affecting plant innate immunity, SA has also been implicated in other cellular processes, such as flowering time determination, lipid metabolism, circadian clock control, and abiotic stress responses, possibly contributing to the regulation of plant development. The multifaceted function of SA makes it critically important to further identify genes involved in SA signaling networks, understand their modes of action, and delineate interactions among the |
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components of SA signaling networks. In addition, genetic manipulation of genes involved in SA signaling networks has also provided a promising approach to enhance disease resistance in economically important plants. This ebook collects articles in the Research Topic "Salicylic Acid Signaling Networks". For this collection we solicited reviews, perspectives, and original research articles that highlight recent exciting progress on the understanding of molecular mechanisms underlying SA-mediated defense, SA-crosstalk with other pathways and how microbes impact these events. |
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