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1. |
Record Nr. |
UNINA9910154677603321 |
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Autore |
Gazan Sissel-Jo <1973-> |
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Titolo |
The arc of the swallow / / S.J. Gazan ; translated from the Danish by Charlotte Barslund |
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ISBN |
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Disciplina |
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Soggetti |
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Marhauge, Søren (Fictitious character) |
Murder - Investigation - Denmark |
Suspense fiction |
Vaccination - Research |
Murder - Investigation |
Mentors - Fiction |
Vaccination - Fiction |
Murder - Investigation - Fiction |
Fiction |
Thrillers (Fiction) |
Mystery fiction |
Denmark |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Biology Ph.D. candidate Marie Skov is devastated when, on the same day as her mother's death, her mentor Kristian Storm apparently kills himself. Storm had been facing academic dishonesty charges, as well as heated criticism of his research on a vaccine for African children--that suggested the vaccine was causing more harm than it was preventing. Skov is skeptical that the death was a suicide. She knows Storm's research on the vaccine was sound, and learns that his on-site work in Guinea-Bissau was marred by intimidation, sabotaged data, and the suspicious death of another scientist. She also learns that in his final days, Storm felt he was being followed by a blue Ford with tinted |
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windows. Soon afterward, a blue Ford with tinted windows parks across from Skov's home. The police have no interest in re-examining the official narrative. But Marhauge shares Skov's desire for answers, and defies his superiors to help her investigate. They receive unlikely help from a Nobel Prize-winning rival of Storm's, and find themselves on a perilous trail that leads to Big Pharma and the World Health Organization. |
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2. |
Record Nr. |
UNINA9910155331803321 |
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Titolo |
The Glutamate/GABA-Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis / / edited by Arne Schousboe, Ursula Sonnewald |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
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Edizione |
[1st ed. 2016.] |
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Descrizione fisica |
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1 online resource (X, 416 p. 55 illus., 42 illus. in color.) |
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Collana |
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Advances in Neurobiology, , 2190-5215 ; ; 13 |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Introduction to the Glutamate-Glutamine cycle -- Glucose, lactate, β-hydroxybutyrate, acetate, GABA, and succinate as substrates for synthesis of glutamate and GABA in the glutamine-glutamate/GABA cycle -- Anaplerosis for glutamate synthesis in the neonate and in adulthood -- Enzyme complexes important for the glutamate-glutamine cycle -- BCAA metabolism and NH3 homeostasis -- Glutaminases Vesicular Glutamate Uptake -- The glutamine transporters and their role in the Glutamate/GABA-Glutamine Cycle -- Glutamine Metabolism in Gliomas -- Oligodendrocytes: development, physiology and glucose metabolism -- Dysregulation of glutamate cycling mediates methylmercury-induced neurotoxicity -- Astroglia, glutamatergic transmission and psychiatric diseases -- Glutamine Synthetase: Role in Neurological Disorders -- The Glutamate – Glutamine Cycle in Epilepsy -- Index. |
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Sommario/riassunto |
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Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction. |
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3. |
Record Nr. |
UNINA9910891647203321 |
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Titolo |
Amérindia |
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ISSN |
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Descrizione fisica |
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Soggetti |
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Indians - Languages |
Indians |
Anthropological linguistics |
Ethnolinguistique |
Langues indiennes d'Amérique |
Indiens d'Amérique |
Indianentalen |
Eskimotaal |
Periodicals. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Periodico |
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Note generali |
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"Revue d'ethnolinguistique amérindienne." |
Some issues have distinctive titles. |
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