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Record Nr. |
UNINA9910155108403321 |
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Autore |
Mallinckrodt Craig H. <1958, > |
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Titolo |
Analyzing longitudinal clinical trial data : a practical guide / / by Craig Mallinckrodt and Ilya Lipkovich |
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Pubbl/distr/stampa |
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Boca Raton, FL : , : Chapman and Hall/CRC, an imprint of Taylor and Francis, , 2016 |
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ISBN |
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1-351-73768-6 |
1-315-18663-2 |
1-351-73769-4 |
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Descrizione fisica |
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1 online resource (330 pages) : illustrations, tables |
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Collana |
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Chapman & Hall/CRC Biostatistics Series |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface -- Acknowledgments -- List of Tables -- List of Figures -- List of Code Fragments -- Section I: Background and Setting -- 1: Introduction -- 2: Objectives and Estimands�Determining What to Estimate -- 3: Study Design�Collecting the Intended Data -- 4: Example Data -- 5: Mixed-Effects Models Review -- Section II: Modeling the Observed Data -- 6: Choice of Dependent Variable and Statistical Test -- 7: Modeling Covariance (Correlation) -- 8: Modeling Means Over Time -- 9: Accounting for Covariates -- 10: Categorical Data -- 11: Model Checking and Verification -- Section III: Methods for Dealing with Missing Data -- 12: Overview of Missing Data -- 13: Simple and Ad Hoc Approaches for Dealing with Missing Data -- 14: Direct Maximum Likelihood -- 15: Multiple Imputation -- 16: Inverse Probability Weighted Generalized Estimated Equations -- 17: Doubly Robust Methods -- 18: MNAR Methods -- 19: Methods for Incomplete Categorical Data -- Section IV: A Comprehensive Approach to Study Development and Analyses -- 20: Developing Statistical Analysis Plans -- 21: Example Analyses of Clinical Trial Data -- References -- Index. |
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Sommario/riassunto |
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Analyzing Longitudinal Clinical Trial Data: A Practical Guide provides practical and easy to implement approaches for bringing the latest theory on analysis of longitudinal clinical trial data into routine |
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