Carbohydrates as Drugs / / edited by Peter H. Seeberger, Christoph Rademacher

• Record Nr.: UNINA9910298645503321
• Pubbl/distr/stampa: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014
• ISBN: 3-319-08675-8
• Edizione: [1st ed. 2014.]
• Descrizione fisica: 1 online resource (242 p.)
• Collana: Topics in Medicinal Chemistry, , 1862-2461 ; ; 12
• Disciplina: 615.3
• Soggetti: Pharmaceutical chemistry; Carbohydrates; Molecular biology; Medicinal Chemistry; Carbohydrate Chemistry; Molecular Medicine
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Carbohydrate-Based Synthetic Chemistry in the Context of Drug Design -- Iminosugars: Therapeutic Applications and Synthetic Considerations -- Computational Docking as a Tool for the Rational Design of Carbohydrate-Based Drugs -- Discovery and Development of Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Dapagliflozin for the Treatment of Type 2 Diabetes -- Design, Synthesis, and Applications of Galectin Modulators in Human Health -- Discovery and Application of FimH Antagonists -- Carbohydrate-Based Anti-Virulence Compounds Against Chronic Pseudomonas aeruginosa Infections with a Focus on Small Molecules -- The Evolution of a Glycoconjugate Vaccine for Candida albicans.
• Sommario/riassunto: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is ; uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Commensurabilities among Lattices in PU (1,n). (AM-132), Volume 132 / / G. Daniel Mostow, Pierre Deligne

• Record Nr.: UNINA9910154745503321
• Autore: Deligne Pierre
• Pubbl/distr/stampa: Princeton, NJ : , : Princeton University Press, , [2016]; ©1994
• ISBN: 1-4008-8251-6
• Descrizione fisica: 1 online resource (196 pages) : illustrations
• Collana: Annals of Mathematics Studies ; ; 313
• Disciplina: 515/.25
• Soggetti: Hypergeometric functions; Monodromy groups; Lattice theory
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Bibliographic Level Mode of Issuance: Monograph
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: Frontmatter -- CONTENTS -- ACKNOWLEDGMENTS -- §1. INTRODUCTION -- §2. PICARD GROUP AND COHOMOLOGY -- §3. COMPUTATIONS FOR Q AND Q+ -- §4. LAURICELLA'S HYPERGEOMETRIC FUNCTIONS -- §5. GELFAND'S DESCRIPTION OF HYPERGEOMETRIC FUNCTIONS -- §6. STRICT EXPONENTS -- §7. CHARACTERIZATION OF HYPERGEOMETRIC-LIKE LOCAL SYSTEMS -- §8. PRELIMINARIES ON ; MONODROMY GROUPS -- §9. BACKGROUND HEURISTICS -- §10. SOME COMMENSURABILITY THEOREMS -- §11. ANOTHER ISOGENY -- §12. COMMENSURABILITY AND DISCRETENESS -- §13. AN EXAMPLE -- §14. ORBIFOLD -- §15. ELLIPTIC AND EUCLIDEAN μ'S, REVISITED -- §16. LIVNE'S CONSTRUCTION OF LATTICES IN PU(1,2) -- §17. LIN E ARRANGEMENTS: QUESTIONS -- Bibliography
• Sommario/riassunto: The first part of this monograph is devoted to a characterization of hypergeometric-like functions, that is, twists of hypergeometric functions in n-variables. These are treated as an (n+1) dimensional vector space of multivalued locally holomorphic functions defined on the space of n+3 tuples of distinct points on the projective line P modulo, the diagonal section of Auto P=m. For n=1, the characterization may be regarded as a generalization of Riemann's classical theorem characterizing hypergeometric functions by their exponents at three singular points. This characterization permits the authors to compare monodromy groups corresponding to different parameters and to prove commensurability modulo inner automorphisms of PU(1,n). The book includes an investigation of elliptic and parabolic monodromy groups, as well as hyperbolic monodromy groups. The former play a role in the proof that a surprising number of lattices in PU(1,2) constructed as the fundamental groups of compact complex surfaces with constant holomorphic curvature are in fact conjugate to projective monodromy groups of hypergeometric functions. The characterization of hypergeometric-like functions by their exponents at the divisors "at infinity" permits one to prove generalizations in n-variables of the Kummer identities for n-1 involving quadratic and cubic changes of the variable.