Biomedical vibrational spectroscopy [[electronic resource] /] / edited by Peter Lasch, Janina Kneipp

• Record Nr.: UNINA9910145696303321
• Pubbl/distr/stampa: Hoboken, N.J., : John Wiley & Sons, c2008
• ISBN: 1-281-28520-X; 9786611285203; 0-470-28317-3; 0-470-28316-5
• Descrizione fisica: 1 online resource (403 p.)
• Altri autori (Persone): KneippJanina; LaschPeter
• Disciplina: 535.8/42; 535.842
• Soggetti: Diagnostic imaging; Infrared spectroscopy; Raman spectroscopy
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: BIOMEDICAL VIBRATIONAL SPECTROSCOPY; CONTENTS; Preface; Contributors; 1 VIBRATIONAL SPECTROSCOPY IN MICROBIOLOGY AND MEDICAL DIAGNOSTICS; 1.1 Vibrational Spectra in Biomedicine Provide Fingerprint-like Signatures of Biological Structures; 1.2 Different Technical Options to Obtain the Spectral Information; 1.3 The Need for and Benefit from Data Evaluation; 1.4 Perspectives of Biomedical Vibrational Spectroscopy; 2 BIOMEDICAL VIBRATIONAL SPECTROSCOPY - TECHNICAL ADVANCES; 2.1 Introduction; 2.2 Measurement Techniques for Clinical Chemistry; 2.3 Measurement Techniques for Pathology; 2.4 Measurement Techniques for In Vivo Spectroscopy2.5 Concluding Remarks; Acknowledgments; References; 3 BIOMEDICAL APPLICATIONS OF INFRARED MICROSPECTROSCOPY AND IMAGING BY VARIOUS MEANS; 3.1 Introduction; 3.2 Specimen Sources, Experimental Schemes, and Optical Substrates; 3.3 Applications; 3.4 Instrumental Means of Biomedical IMS; 3.5 Comment; Acknowledgments; Acronyms and ; Trademarks; References; 4 INFRARED SPECTROSCOPY OF BIOFLUIDS IN CLINICAL CHEMISTRY AND MEDICAL DIAGNOSTICS; 4.1 Introduction; 4.2 Vibrational Spectroscopy of Biofluids; 4.3 Quantification (Regression) and Diagnostic (Classification) Approaches4.4 Quantitative Biofluid Analysis; 4.5 Diagnostic Biofluid Tests; 4.6 Veterinary Applications; 4.7 Microfluidics and IR Spectroscopy of Biofluids; 4.8 Concluding Remarks; References; 5 RAMAN SPECTROSCOPY OF BIOFLUIDS; 5.1 Introduction; 5.2 Background Fluorescence; 5.3 The Putative Drawback of a Low Signal-to-Noise-Ratio; 5.4 Spectroscopy of Blood and Its Derivates; 5.5 In Vitro Raman Spectroscopy of Serum for Laboratory Diagnostics: A Case Study; 5.6 Raman Spectroscopy of Body Fluids In Vivo; 5.7 Raman Spectroscopy of Other Body Fluids5.8 Summary; Acknowledgments; References; 6 VIBRATIONAL MICROSPECTROSCOPY OF CELLS AND TISSUES; 6.1 Introduction; 6.2 Infrared Histopathology: IR Microspectroscopic Mapping of Tissues; 6.3 Vibrational Cytology: IR and Raman Spectroscopy of Eukaryotic Cells; 6.4 Concluding Remarks; Acknowledgments; References; 7 RESONANCE RAMAN MICROSPECTROSCOPY AND IMAGING OF HEMOPROTEINS IN SINGLE LEUKOCYTES; 7.1 Hemoproteins; 7.2 Raman Microspectroscopy; 7.3 Outline of This Chapter; 7.4 Instrumentation and Spectral Data Analysis; 7.5 Resonance Raman Microspectroscopy on Neutrophilic Granulocytes7.6 Resonance Raman Microscopy on Neutrophilic Granulocytes; 7.7 Photobleaching and Light-Induced Cell Damage in Resonance Raman Microspectroscopy; 7.8 Concluding Remarks; Acknowledgments; References; 8 RESONANT RAMAN SCATTERING OF HEME MOLECULES IN CELLS AND IN THE SOLID STATE; 8.1 Introduction; 8.2 Electronic Structure of Heme Moieties; 8.3 Resonance Raman Spectroscopy; 8.4 Resonance Raman Spectroscopy of Hemes in Cells and the Solid State; 8.5 Resonance Raman of Heme Derivatives Using Near-Infrared Excitation in the Solid State
• Sommario/riassunto: This comprehensive overview of biomedical applications of vibrational spectroscopy focuses on methodologies that are most relevant to biodiagnostics. After a few introductory chapters that summarize the current status of the field, the reference covers current spectroscopic applications; new spectroscopic directions; and study design and the analysis of vibrational spectral fingerprints from complex biological and clinical samples . With chapters contributed by leading international experts, Biomedical Vibrational Spectroscopy is a core resource.