Understanding differences and disorders of sex development (DSD) / / volume editors O. Hiort, S. F. Ahmed

• Record Nr.: UNINA9910163018703321
• Pubbl/distr/stampa: Basel, Switzerland : , : S. Karger AG, , 2014; ©2014
• ISBN: 3-318-02559-3
• Descrizione fisica: 1 online resource (312 p.)
• Collana: Endocrine Development, , 1662-2979 ; ; Volume 27
• Disciplina: 616.6/94
• Soggetti: Intersexuality - History; Sex differentiation - Endocrine aspects
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: "28 figures, 12 in color, and 26 tables, 2014"--Cover.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: ""Cover""; ""Front Matter""; ""Contents""; ""Foreword""; ""Preface""; ""Concepts""; ""Gonadal Development""; ""Abstract""; ""Molecular Determinants of the Bipotential Gonad""; ""Molecular Determinants of Testis""; ""Molecular Determinants of the Ovary""; ""Conclusions""; ""Acknowledgements""; ""References""; ""The Masculinization Programming Window""; ""Abstract""; ""Reproductive Tract Development and Differentiation""; ""Internal Reproductive Organ Differentiation""; ""Differentiation of the External Genitalia""; ""Masculinization Programming Window in Males""; ""Clinical Implications of the MPW in Males""""Masculinization Programming Window in Females""; ""Anogenital Distance""; ""Modulation of Androgen Signal through Conditional Mutant Mice""; ""Conclusion""; ""References""; ""Androgen Action""; ""Abstract""; ""The Androgen Receptor""; ""Genomic Action of the Androgen Receptor""; ""Programming Androgen Actions""; ""Summary""; ""Acknowledgements""; ""References""; ""Technological Advances""; ""Steroid Biochemistry""; ""Abstract""; ""Steroidogenesis""; ""Measurement of Steroids in Body Fluids""; ""Defining of Specific Conditions""; ""Conclusions and Future Perspective""""References""; ""Next Generation Sequencing for Disorders of Sex Development""; ""Abstract""; ""Whole Genome or Exome?""; ""Not All Exome Datasets Are the Same""; ; ""Reporting Next Generation Sequencing Results""; ""Multiple Next Generation Sequencing Approaches to Understand Disorders of Sex Development""; ""Conclusions""; ""Acknowledgements""; ""References""; ""Advances in Neuroimaging""; ""Abstract""; ""Computed Tomography""; ""Magnetic Resonance Imaging""; ""Single Photon Emission Computed Tomography and Positron Emission Tomography""; ""Functional Magnetic Resonance Imaging""""Magnetic Resonance Spectroscopy""; ""Diffusion Tensor Imaging""; ""Sexual Dimorphism of Brain Structure and Function""; ""Structural Differences""; ""Functional Differences""; ""Neuroimaging in Disorders of Sex Development""; ""Conclusion""; ""References""; ""Imaging, Endoscopy and Diagnostic Surgery""; ""Abstract""; ""Techniques""; ""Imaging of the Gonads""; ""Imaging of the Sex Ducts and the Vagina""; ""Imaging of the Genitalia""; ""Very Rare Disorders of Sex Development""; ""Concluding Remarks""; ""References""; ""Fertility Issues in the Management of Patients with Disorders of Sex Development""""Abstract""; ""Dysgenetic Disorders of Sex Development""; ""46,XY Disorder of Sex Development due to Abnormal Testicular Hormone Synthesis or Action""; ""46,XX Disorders of Sex Development due to Excessive Androgen Exposure""; ""References""; ""Communication""; ""Disorders of Sex Development Peer Support""; ""Abstract""; ""History of Disorders of Sex Development Peer Support""; ""Value of Peer Support: Evaluation of the Evidence and Lessons to Be Learned""; ""Current Peer Support in Disorders of Sex Development""
• Sommario/riassunto: Ten years ago a group of experts assembled in Chicago to develop a consensus on the management of conditions previously described as intersex. The consequences of this consensus have been far reaching, including a change in nomenclature, the development of greater collaboration across geographical boundaries, and a move towards greater involvement of patients and parents. Moreover, an international registry was established, as well as research and clinical networks. This book brings together a thorough overview on all these topics. Furthermore, the major technological advances in diagnostic genetic and biochemical capabilities over the past 10 years are outlined in detail. Offering a comprehensive update on various aspects of disorders of sex development (DSD), this book will be essential reading to all clinicians who are involved in delivering health care to patients with a DSD, as well as scientists involved in biomedical research related to DSD.

The microbiology of safe food / / S.J. Forsythe

• Record Nr.: UNINA9910145299503321
• Autore: Forsythe S. J (Steve J.)
• Pubbl/distr/stampa: Oxford ; ; Malden, MA : , : Blackwell Science, , 2000
• ISBN: 1-281-31278-9; 9786611312787; 0-470-99943-8; 0-470-99942-X
• Descrizione fisica: 1 online resource (x, 412 pages) : illustrations
• Disciplina: 664.001; 664.001579
• Soggetti: Food - Microbiology; Food - Safety measures; Food law and legislation
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: THE MICROBIOLOGY OF SAFE FOOD; CONTENTS; Preface; 1 Introduction to Safe Food; 1.1 What is safe food?; 1.2 The manufacture of hygienic food; 1.3 Functional foods; 2 Basic Aspects; 2.1 The microbial world; 2.2 Bacterial cell structure; 2.3 Microbial growth cycle; 2.4 Death kinetics; 2.5 Factors affecting microbial growth; 2.6 Preservatives; 2.7 Microbial response to stress; 2.8 Predictive modelling; 3 Foodborne Illness; 3.1 The size of the food poisoning problem; 3.2 Consumer pressure effect on food processing; 3.3 Testing foods for the presence of pathogens; 3.4 Control of food poisoning; 3.5 Surveillance programmes; 3.6 Causes of food poisoning; 3.7 The microbial flora of the human gastrointestinal tract; 3.8 The mode of action of bacterial toxins; 3.9 Virulence factors of foodborne pathogens; 4 The Microbial Flora of Food; 4.1 Spoilage microorganisms; 4.2 Shelf life indicators; 4.3 Methods of preservation and shelf life extension; 4.4 Fermented foods; 4.5 Prebiotics, probiotics and synbiotics; 4.6 Microbial biofilms; 5 Food Poisoning Microorganisms; 5.1 Indicator organisms; 5.2 Foodborne pathogens: bacteria; 5.3 Foodborne pathogens: viruses; 5.4 Seafood and shellfish ; poisoning; 5.5 Foodborne pathogens: eucaryotes; 5.6 Mycotoxins; 5.7 Emerging and uncommon foodborne pathogens; 6 Methods of Detection; 6.1 Prologue; 6.2 Conventional methods; 6.3 Rapid methods; 6.4 Rapid end-detection methods; 6.5 Specific detection procedures; 6.6 Accreditation schemes; 7 Food Safety Management Tools; 7.1 Microbiological safely of food in world trade; 7.2 The management of hazards in food which is in international trade; 7.3 Hazard Analysis Critical Control Point (HACCP); 7.4 Outline of HACCP; 7.5 Microbiological criteria and HACCP; 7.6 Microbiological hazards and their control; 7.7 HACCP plans; 7.8 Sanitation Standard Operating Procedures (SSOPs); 7.9 Good Manufacturing Practice (GMP) and Good Hygiene Practice (GHP); 7.10 Quality Systems; 7.11 Total Quality Management (TQM); 7.12 ISO 9000 Series of standards; 8 Microbiological Criteria; 8.1 International Commission on Microbiological Specifications for Foods; 8.2 Codex Alimentarius principles for the establishment and application of microbiological criteria for foods; 8.3 Sampling plans; 8.4 Variables plans; 8.5 Attributes sampling plan; 8.6 Principles; 8.7 Microbiological limits; 8.8 Examples of sampling plans; 8.9 Implemented microbiological criteria; 8.10 Public Health (UK) Guidelines for Ready-To-Eat Foods; 9 Microbiological Risk Assessment; 9.1 Risk assessment (RA); 9.2 Risk management; 9.3 Risk communication; 9.4 Food Safety Objectives; 9.5 Application of MRA; 10 Regulations and Authorities; 10.1 Regulations in international trade of food; 10.2 Codex Alimentarius Commission; 10.3 Sanitary and Phytosanitary measures (SPS), Technical Barriers to Trade (TBT) and the World Health Organisation (WHO); 10.4 Food authorities in the United States; 10.5 European Union legislation; 10.6 Food safety agencies; Glossary of Terms
• Sommario/riassunto: The book will provide an overview of the important issues in food safety, which shows no sign of diminishing as a topic of huge concern from industry to consumer. The book does not set out to compete with large standard food microbiology titles that are well established, but will be a companion text with less scientific background detail and more information for those actually going into jobs where a practical knowledge of food safety issues is necessary. The companion website for this book can be found at: http://www.foodmicrobe.com/info.htm.