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Record Nr. |
UNINA9910145117303321 |
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Titolo |
The Ocala banner |
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Pubbl/distr/stampa |
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Ocala, Marion County, Fla., : Banner Pub. Co., 1883- |
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Descrizione fisica |
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Soggetti |
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Ocala (Fla.) Newspapers |
Marion County (Fla.) Newspapers |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Periodico |
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Note generali |
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Editors: T.W. Harris, F.E. Harris, C.L. Bittinger. |
Publisher varies: Frank Harris & Frank Harris, Jr., <1913. |
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Sommario/riassunto |
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The East Florida Banner [LCCN: sn84022783] first started publishing weekly in Marion County, Florida in 1866. The Florida Newspaper Chronology, promulgated by David Shedden at the Poynter Institute for Media Studies in St. Petersburg, FL, lists a variant for the initial appearance of the newspaper, the East Marion Banner [LCCN: not known to exist]. The East Florida Banner described itself as "Democratic" and as the "Official Organ of the 5th Judicial Circuit"-. It is the direct forerunner of today's Star-Banner [LCCN: sn95005532]. The East Florida Banner was sold to George W. Wilson in 1881, and renamed The Florida Banner-Lacon [LCCN: sn95047283], having merged with the Florida Lacon [LCCN: not known to exist]. In 1883, the name was changed to the Ocala (FL) Banner [LCCN: sn88074815]. In 1890, it became a daily newspaper. In 1895, the Ocala (FL) Evening Star [LCCN: sn84027621] surfaced as a rival publication to the Ocala Banner.- |
They subsequently joined merged into one publication on September 1, 1943. The resulting Ocala (FL) Star-Banner [LCCN: sn78002071] has remained the daily newspaper in Marion County (FL) since that time. The Ocala Banner bore the alternate titles the Banner, the Daily Banner, and the Ocala Daily Banner. A daily edition, published between 1908 and 1920, is thought to have existed, but its title is unknown. Another daily edition, the Ocala Morning Banner was published between 1930 |
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and 1943. R.N. Dosh, editor of the Ocala Evening Star in the 1920s and 1930s, gave an address to the Ocala Rotary Club, recalling by-gone editors and rival publications, chiefest of whom was Col. Frank E. Harris of the Ocala Banner in the 1890s. Frank E. Harris was sent to Florida to fight in the Seminole Wars. He later fought in the Civil War on the side of the Confederacy in the First Florida Infantry Regiment. Other editors included T.W. Harris and C.L. Bittinger. T.W.- |
Harris also published the daily, except Mondays, Daily Item (Ocala, FL) [LCCN sn95026901], from 1885 through 1886 and the weekly Rural Free Press (Ocala, FL) [LCCN sn95072056] from 1886 through at least 1888. Before moving to Florida, C.L. Bittinger had served as a commander in the Grand Army of the Republic during the Civil War. His only known newspaper work was with the Ocala Banner. Ocala (FL) is the seat of Marion County (FL) government. The Freeze of 1894 dramatically changed Ocala, devastating the citrus industry in Marion County. Between 1883 and 1943, other forms of agriculture took the place of citrus while tourism in the area grew. The Silver Springs theme park, known for its crystal clear waters, would do its part like no other attraction in pre-World War II Marion County. The County remained primarily agricultural until after the war, when its character would again change dramatically. The Ocala Banner covered agriculture, tourism and civic issues. --E.- |
Kesse, University of Florida Digital Library Center. |
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2. |
Record Nr. |
UNINA9910220049403321 |
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Autore |
Brian J. Arey |
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Titolo |
The Physiology and Pharmacology of Leucine-rich Repeat GPCRs |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (115 p.) |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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G protein-coupled receptors (GPCRs) represent a large and physiologically important class of cell surface receptors. There are approximately 750 known GPCRs present in the human genome that can be subdivided into general classes based upon sequence homology within their transmembrane domains. Therapeutically, GPCRs represent a fertile source for the development of therapies as they are a significant percentage of our current pharmacopeia. Among the three subclasses of GPCRs, the Class A (rhodopsin-like) receptors are by far the most prevalent and extensively studied. However, within the Class A receptors, sub-families of receptors can be distinguished based upon common sequence motifs within the transmembrane domains as well as extracellular and intracellular domains. One such family of Class A receptors is characterized by multiple leucine- rich repeats within their amino- terminal domains (the Leucine-rich Repeat family (LRR)). This family of GPCRs are best represented by the glycoprotein hormone receptors (LHR, FSHR and TSHR) which have been studied extensively but also includes receptors for the peptide hormone relaxin (RXFP1 and RXFP2 (RXFP2 also binds insulin-like peptide 3)) and three other receptors (LGR4, LGR5 and LGR6). LGR4-6 were, until recently, considered orphan receptors. However, emerging data have revealed that these proteins are the receptors for a family of growth factors called R-spondins. Over the last 20 years much has been learned about LRR receptors, including the development of synthetic agonists and |
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antagonists, new insights into signaling (including signaling bias) and the physiological role these receptors play in regulating the function of many tissues. This topic will focus on what is known concerning the regulation of these receptors, their signaling pathways, functional consequences of activation and pharmacology. |
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