1.

Record Nr.

UNINA9910144736403321

Titolo

Vaccines against virally induced cancers [[electronic resource]]

Pubbl/distr/stampa

Chichester ; ; New York, : J. Wiley, 1994

ISBN

1-282-13792-1

9786612137921

0-470-51467-1

0-470-51468-X

Descrizione fisica

1 online resource (293 p.)

Collana

Ciba Foundation symposium ; ; 187

Altri autori (Persone)

FrazerI. H (Ian H.)

Disciplina

616.99

616.992061

Soggetti

Viral carcinogenesis

Viral vaccines

Cancer - Immunotherapy

Electronic books.

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

"Ciba Foundation"--Cover.

Symposium held at the Ciba Foundation, London, 15-17 March 1994, based on a proposal by Ian Frazer.

Nota di bibliografia

Includes bibliographical references and indexes.

Nota di contenuto

VACC I N ES AGAl NST VIRALLY INDUCED CANCERS; Contents; Participants; Introdu ction; Potential antigenic targets on Epstein - Bar r vir us-associated tumours and the host response; The host response to lesions induced by human papillomavirus; General discussion I; Human T cell lymphotropic virus: necessity for and feasibility of a vaccine; Vaccination against cutaneous and mucosal papillomavirus in cattle; Strategies for studying mouse and human immune responses to human papillomavirus type 16

Prospects for T cell immunotherapy of tumours by vaccination with immunodominant and su bdominant peptidesHepatitis B virus infection, the immune response and hepatocellular carcinoma; The role of superantigens in the immunobiology of retroviruses; General discussion I I; Assembly and transport of class I MHC-peptide complexes; Induction and regulation of CD4+ T cell subsets; Propagation of mouse and human T cells with defined antigen



specificity and function; Immunity to the HER-2heu oncogenic protein

Genetic modification of T cell clones to improve the safety and efficacy of adoptive T cell therapyBone marrow-derived cells present MHC class I-restricted tumour antigens in priming of antiturnour immune responses; Evasion of host immune responses by tumours and viruses; Final dscussion; Index of contributors; Subject index

Sommario/riassunto

An interdisciplinary and multinational group of specialists present contributions describing the current status of vaccines against virally induced tumors and discuss the means by which they can be improved.