Immunological tolerance [[electronic resource] /] / [editors, Gregory R. Bock (organizer) and Jamie A. Goode]

• Record Nr.: UNINA9910144736103321
• Pubbl/distr/stampa: Chichester ; ; New York, : J. Wiley & Sons, 1998
• ISBN: 1-282-12249-5; 9786612122491; 0-470-51552-X; 0-470-51553-8
• Descrizione fisica: 1 online resource (250 p.)
• Collana: Novartis Foundation symposium ; ; 215
• Altri autori (Persone): BockGregory; GoodeJamie
• Disciplina: 571.96; 616.079
• Soggetti: Immunological tolerance; Autoimmunity; Electronic books.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: "Symposium on Immunological Tolerance, held at the Novartis Foundation, London, 8-10 July 1997"--P. v.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: IMMUNOLOGICAL TOLERANCE; Contents; Participants; Introduction; Mechanisms of peripheral T cell tolerance; B cell antigen receptor signalling in the balance of tolerance and immunity; General discussion I; The study of self-tolerance using murine haemoglobin as a model self antigen; Tolerance and determinant hierarchy; Molecular genetic studies in lymphocyte apoptosis and human autoimmunity; General discussion II; A role for CTLA-4-mediated inhibitorv J signals in peripheral T cell tolerance?; Antigen-specific CD4+ T cells that survive after the induction of peripheral tolerance possess an intrinsic lymphokine production defectAntigen-specific tolerance induction and the immunotherapy of experimental autoimmune disease; Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes; Tolerance induction with CD4 monoclonal antibodies; A two-step model for the induction of organ-specific autoimmunity; Cross-presentation of self ; antigens to CDW T cells: the balance between tolerance and autoimmunity; General discussion III; Tolerance induction in mature T lymphocytesT lymphocyte-mediated control of autoimmunity; Final general discussion; Index of contributors; Subject index
• Sommario/riassunto: This book brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Careful consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T cell activation during tumour therapy, antiantigen specific immune suppression, tolerance in infectious diseases, tolerance during