Environmental chemicals, enzyme function, and human disease

• Record Nr.: UNINA9910144657003321
• Pubbl/distr/stampa: Amsterdam ; ; New York : , : Excerpta Medica; New York : , : Elsevier/North-Holland, , 1980
• ISBN: 1-280-78392-3; 9786613694317; 0-470-72059-X; 0-470-71827-7
• Descrizione fisica: 1 online resource (392 pages)
• Collana: Ciba Foundation symposium (new series) ; ; 76.
• Disciplina: 615.9
• Soggetti: Toxicology; Drugs - Metabolism; Enzyme induction; Biotransformation (Metabolism)
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: "Symposium on Drug-Metabolizing Enzymes and Environmental Chemicals: Toxic Interactions, held at the Ciba Foundation, London, 23-25 October 1979"--Participants page.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: Environmental Chemicals Enzyme Function and Human Disease; Contents; Chairman's introduction; The role of the drug-metabolizing enzymes; Discussion; The influence of inducers on drug-metabolizing enzyme activity and on formation of reactive drug metabolites in the liver; Discussion; Effects of inducers and inhibitors on drug-metabolizing enzymes and on drug toxicity in extrahepatic tissues; Discussion; Induction of enzymes involved in DNA repair and mutagenesis; Discussion; Induction of drug-metabolizing enzymes by polycyclic aromatic hydrocarbons: mechanisms, and some implications in environmental health research; Discussion; Discussion; Induction of drug-metabolizing enzymes by phenobarbitone: structural and biochemical aspects; Substrate-dependent irreversible inactivation of cytochrome P-450: conversion of its haem moiety into modified porphyrins; Discussion; General Discussion I; Regulation of human drug ; metabolism by dietary factors; Discussion; Influence of foreign compounds on formation and disposition of reactive metabolites; Discussion; Pharmacokinetic factors governing the steady-state concentrations of foreign chemicals and their metabolites; Discussion; Toxicological implications of polymorphic drug metabolism; Immunologically mediated toxicity; Discussion; Toxicological significance of liver hypertrophy produced by inducers of drug-metabolizing enzymes; Discussion; Discussion; Discussion; The influence of nutrition and inducers on mechanisms of toxicity in humans and animals; Influence of environmental chemicals on drug therapy in humans: studies with contraceptivesteroids; Discussion; General Discussion II; Vitamin D metabolism in patients treated with phenytoin and phenobarbitone; Discussion; Chemical disease in humans: problems in comparative toxicology; Discussion; Implications for future studies in humans; Final General Discussion; Index of Contributors; Subject Index