Epigenetics

• Record Nr.: UNINA9910144559903321
• Pubbl/distr/stampa: Chichester, [England] : , : John Wiley & Sons, , 1998; ©1998
• ISBN: 1-282-34808-6; 9786612348082; 0-470-51550-3; 0-470-51551-1
• Descrizione fisica: 1 online resource (320 p.)
• Collana: Novartis Foundation Symposium ; ; 214
• Altri autori (Persone): ChadwickDerek; CardewGail
• Disciplina: 572.8; 572.865
• Soggetti: Genetic regulation; Epigenesis; DNA - Methylation; Electronic books.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: EPIGENETICS; Participants; Contents; Introduction; Gene silencing by methyl-CpG- binding proteins; DNAmethylation, nucleosornes and the inheritance okhromatin structure and function; General discussion I; Heritable chromatin states induced by the Polycomb and trithorax group genes; The dynamics of globin gene expression and position effects; Multiple epigenetic events regulate mating-type switching of fission yeast; General discussion I1; Nuclear organization and silencing: trafficking of Sir proteins; Epigenetic mechanisms in the regulation of the maize Suppressor-mutator transposon; Transgene-promoted epigenetic switches of chalcone synthase activity in petunia plantsGeneral discussion I11; Gene silencing in plants: relevance for genome evolution and the acquisition of genomic methylation patterns; The host defence function of genomic methylation patterns; Mammalian X chromosome inactivation; ; Methylation dynamics, epigenetic fidelity and X chromosome structure; General discussion IV; Imprinting and gene silencing in mice and DrosophiZa; Making sense of imprinting the mouse and human IGF2R loci; Imprinted genes in the Prader-Willi deletion; Final general discussion; SummaryIndex of contributors; Subject index
• Sommario/riassunto: Epigenetics pertains to the development of an organism from an undifferential cell, resulting in the successive formation and development of organs and parts that did not pre-exist in the fertilized egg. An exciting and stimulating volume which used the extensive knowledge of basic transcriptional control as a foundation to explore the more complex and interesting level at which genes can be regulated.