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1. |
Record Nr. |
UNINA9910144402103321 |
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Titolo |
Fragment-based drug discovery [[electronic resource] ] : a practical approach / / editors, Edward R. Zartler, Michael J. Shapiro |
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Pubbl/distr/stampa |
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Chichester, U.K., : John Wiley & Sons, 2008 |
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ISBN |
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1-282-34275-4 |
9786612342752 |
0-470-72155-3 |
0-470-72156-1 |
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Descrizione fisica |
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1 online resource (297 p.) |
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Altri autori (Persone) |
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ZartlerEdward |
ShapiroMichael (Michael J.) |
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Disciplina |
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Soggetti |
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Drug development |
Drugs - Design |
Ligands (Biochemistry) |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Fragment-Based Drug Discovery; Contents; List of Contributors; 1 Introduction to Fragment-based Drug Discovery; 2 Designing a Fragment Process to Fit Your Needs; 3 Assembling a Fragment Library; 4 Practical Aspects of Using NMR in Fragment-based Screening; 5 Application of Protein-Ligand NOE Matching to the Rapid Evaluation of Fragment Binding Poses; 6 Target-immobilized NMR Screening: Validation and Extension to Membrane Proteins; 7 In Situ Fragment-based Medicinal Chemistry: Screening by Mass Spectrometry; 8 Computational Approaches to Fragment and Substructure Discovery and Evaluation |
9 Virtual Fragment Scanning: Current Trends, Applications and Web-based Tools10 Capture Methods for Fragment-based Discovery; 11 Identification of High-affinity -Secretase Inhibitors Using Fragment-based Lead Generation; Index |
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Sommario/riassunto |
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Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical ti |
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2. |
Record Nr. |
UNINA9910788039103321 |
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Autore |
Nancy Jean-Luc |
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Titolo |
What's these worlds coming to? / / Jean-Luc Nancy and Aurelien Barrau ; translated by Travis Holloway and Flor Mechain |
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Pubbl/distr/stampa |
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New York : , : Fordham University Press, , 2015 |
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©2015 |
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ISBN |
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0-8232-6632-X |
0-8232-6337-1 |
0-8232-6336-3 |
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Edizione |
[First edition.] |
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Descrizione fisica |
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1 online resource (129 p.) |
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Collana |
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Disciplina |
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Soggetti |
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Phenomenology - History - 20th century |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Front matter -- Contents -- Foreword. To Inhabit a World -- Translators’ Preface -- Preamble -- More than One -- Less Than One, Then -- Of Struction -- . . . And of Unistruction -- Notes |
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Sommario/riassunto |
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Our contemporary challenge, according to Jean-Luc Nancy and Aurelien Barrau, is that a new world has stolen up on us. We no longer live in a world, but in worlds. We do not live in a universe anymore, but rather in a multiverse. We no longer create; we appropriate and montage. And we no longer build sovereign, hierarchical political institutions; we form local assemblies and networks of cross-national assemblages— and we |
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do this at the same time as we form multinational corporations that no longer pay taxes to the state. In such a time, one of the world’s most eminent philosophers and an emerging astrophysicist return to the ancient art of cosmology. Nancy and Barrau’s work is a study of life, plural worlds, and what the authors call the struction or rebuilding of these worlds. Nancy and Barrau invite us on an uncharted walk into barely known worlds when an everyday French idiom, “What’s this world coming to?,” is used to question our conventional thinking about the world. We soon find ourselves living among heaps of odd bits and pieces that are amassing without any unifying force or center, living not only in a time of ruin and fragmentation but in one of rebuilding. Astrophysicist Aurelien Barrau articulates a major shift in the paradigm of contemporary physics from a universe to a multiverse. Meanwhile, Jean-Luc Nancy’s essay “Of Struction” is a contemporary comment on the project of deconstruction and French poststructuralist thought. Together Barrau and Nancy argue that contemporary thought has shifted from deconstruction to what they carefully call the struction of dis-order. |
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