1.

Record Nr.

UNINA9910144297903321

Titolo

Photosensitizing compounds [[electronic resource] ] : their chemistry, biology and clinical use

Pubbl/distr/stampa

Chichester ; ; New York, : Wiley, 1989

ISBN

1-282-12236-3

9786612122361

0-470-51384-5

0-470-51385-3

Descrizione fisica

1 online resource (252 p.)

Collana

Ciba Foundation symposium ; ; 146

Disciplina

540

615.8

615.831

Soggetti

Photosensitizing compounds - Therapeutic use - Testing

Photosensitizing compounds

Cancer - Photochemotherapy

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

"A Wiley-Interscience publication."

Nota di bibliografia

Includes bibliographical references and indexes.

Nota di contenuto

PHOTOSENSITIZING COMPOUNDS: THEIR CHEMISTRY, BIOLOGY AND CLINICAL USE; Contents; Introduction; What are the ideal photoproperties for a sensitizer?; The chemistry, photophysics and photosensitizing properties of phthalocyanines; General discussion : Comparison of haematoporphyrin derivative and new photosensitizers; Porphyrins as photosensitizers; Photodynamic therapy: light delivery and dosage for second-generation photosensitizers; In vivo transport and pharmacokinetic behaviour of tumour photosensitizers; Intracellular localization of photosensitizers

Tissue localization of photosensitizers and the mechanism of photodynamic tissue destructionImmunosuppression in phototherapy; Effects of porphyrins on skin; Photosensitizing compounds in the treatment of psoriasis; Extracorporeal photochemotherapy in the treatment of cutaneous T cell lymphoma and autoimmune disorders affecting the skin; Photodynamic therapy of early-stage lung cancer; Long-term experience with integral photodynamic therapy of TIS



bladder carcinoma; Photoradiation therapy of brain tumours; Final general discussion : Drug and light doses for photodynamic therapy

Chairman's summing-upIndex of contributors; Subject index

Sommario/riassunto

Certain organic compounds can become toxic to biological tissue when activated by light. Many medical applications of this effect have been studied over the past twenty years, and This symposium brings together chemists, biologists, and clinicians to discuss the basic chemistry of the sensitizing compounds, their biological effects, and clinical applications in treatments of various cancers and skin disorders.