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Record Nr. |
UNINA9910144297403321 |
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Titolo |
Catalytic antibodies [[electronic resource]] |
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Pubbl/distr/stampa |
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Chichester ; ; New York, : Wiley, 1991 |
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ISBN |
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1-282-34772-1 |
9786612347726 |
0-470-51410-8 |
0-470-51411-6 |
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Descrizione fisica |
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1 online resource (272 p.) |
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Collana |
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Ciba Foundation symposium ; ; 159 |
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Disciplina |
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Soggetti |
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Monoclonal antibodies |
Enzymes |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"A Wiley-Interscience publication." |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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CATALYTIC ANTIBODIES; Contents; Introduction; A catalytic antibody uses a multistep kinetic sequence; Structural aspects of antibodies and antibody-antigen complexes; Nuclear magnetic resonance studies of antibody-antigen interactions; Modelling antibody combining sites: a review; Approaches to the design of semisynthetic metal-dependent catalytic antibodies; Construction of combinatorial antibody expression libraries in Escherichia coli; Catalytic antibodies: contributions from engineering and expression in Escherichia coli |
The generation of antibody combining sites containing catalytic residuesGeneral discussion I; Screening combinatorial antibody libraries for catalytic acyl transfer reactions; Binding and multiple hydrolytic sites in epitopes recognized by catalytic anti-peptide antibodies; Antibody catalysis of carbon-carbon bond formation; Characterization of the mechanism of action of a catalytic antibody; Catalytic antibodies: a new window on protein chemistry; Expanded transition state analogues; Tritylase antibodies; Final general discussion : How good are catalytic antibodies? |
Potential uses of catalytic antibodiesSummary; Index of contributors; |
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