Amino group chemistry : from synthesis to the life sciences / / edited by Alfredo Ricci

• Record Nr.: UNINA9910144276703321
• Pubbl/distr/stampa: Weinheim, [Germany] : , : Wiley-VCH Verlag GmbH & Co. KGaA, , 2008; ©2008
• ISBN: 1-282-78423-4; 9786612784231; 3-527-62126-1; 3-527-62127-X
• Descrizione fisica: 1 online resource (410 p.)
• Classificazione: 35.62
• Disciplina: 547.042; 572/.65
• Soggetti: Amino acids; Electronic books.
• Lingua di pubblicazione: Tedesco
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Amino Group Chemistry; Contents; Preface; List of Contributors; 1 Simple Molecules, Highly Efficient Amination; 1.1 Introduction; 1.2 Hydroxylamine Derivatives; 1.2.1 O-Sulfonylhydroxylamine; 1.2.2 O-Phosphinylhydroxylamine; 1.2.3 O-Acylhydroxylamine; 1.2.4 O-Trimethylsilylhydroxylamine; 1.2.5 Experimental Procedures; 1.3 Oxime Derivatives; 1.3.1 Synthesis of Primary Amines by Electrophilic Amination of Carbanions; 1.3.2 Experimental Procedures; 1.4 Azo Compounds; 1.4.1 Azodicarboxylates; 1.4.1.1 Allylic Amination through Ene-Type Reactions; 1.4.1.2 Hydrohydrazination of Alkenes; 1.4.2 Arylazo Sulfones1.4.3 Experimental Procedures; 1.5 Oxaziridine Derivatives; 1.5.1 Electrophilic Amination of Carbon Nucleophiles; 1.5.2 Amination of Allylic and Propargylic Sulfides by Use of a Ketomalonate-Derived Oxaziridine; 1.5.3 Experimental Procedures; 1.6 Chloramine-T; 1.6.1 Aminochalcogenation of Alkenes; 1.6.2 Aminohydroxylation of Alkenes; 1.6.3 Aziridination of Alkenes; 1.6.4 Other Applications; 1.6.5 Experimental Procedures; 1.7 N-Sulfonyliminophenyliodinane; 1.7.1 ; Transition Metal-Catalyzed Amination of Alkenes; 1.7.2 Experimental Procedures; 1.8 Transition Metal-Nitride Complexes1.8.1 Nitrogen Atom Transfer Mediated by Transition Metal/Nitride Complexes; 1.8.2 Experimental Procedures; 1.9 Azido Derivatives; 1.9.1 Electrophilic Amination of Organometallic Reagents with Organic Azides; 1.9.2 Radical-Mediated Amination with Sulfonyl Azides; 1.9.3 Hydroazidation of Alkenes with Sulfonyl Azides; 1.9.4 Experimental Procedures; 1.10 Gabriel-Type Reagents; 1.10.1 Nucleophilic Amination Reactions; 1.10.2 Experimental Procedure; 1.11 Conclusion; 2 Catalytic C-H Amination with Nitrenes; 2.1 Introduction; 2.2 Historical Overview; 2.3 Hypervalent Iodine-Mediated C-H Amination2.3.1 Intramolecular C-H Amination; 2.3.1.1 From NH(2) Carbamates; 2.3.1.2 From NH(2) Sulfamates; 2.3.1.3 From Other Nitrogen Functionalities; 2.3.2 Intermolecular C-H Amination; 2.3.2.1 General Scope and Limitations; 2.3.2.2 Recent Major Improvements; 2.4 Other Nitrene Precursors for C-H Amination; 2.4.1 Azides; 2.4.2 Haloamines; 2.4.3 Carbamate Derivatives; 2.5 Amination of Aromatic C-H Bonds; 2.6 Applications in Total Synthesis; 2.6.1 Application of Intramolecular C-H Amination with Carbamates; 2.6.2 Application of Intramolecular C-H Amination with Sulfamates2.6.3 Application of Intermolecular C-H Amination; 2.7 Conclusions; 3 Nitroalkenes as Amination Tools; 3.1 Introduction; 3.2 General Strategies for the Synthesis of Nitroalkenes; 3.3 Synthesis of Alkylamines; 3.3.1 Monoamines; 3.3.2 Amino Acid Derivatives; 3.3.3 Amino Alcohols; 3.3.4 Diamino Derivatives; 3.4 Pyrrolidine Derivatives; 3.4.1 Pyrrolidinones; 3.4.2 Pyrrolidines; 3.5 Piperidines and Piperazines; 3.6 Pyrrolizidines and Related Derivatives; 3.7 Arene-Fused Nitrogen Heterocycles; 3.7.1 Pyrroloindole Derivatives; 3.7.2 Carbolines and their Tryptamine Precursors
• Sommario/riassunto: Here, probably the most important functional group in organic chemistry is discussed in one handy volume. The monograph covers its application -- from natural products to synthetic pharmaceuticals -- detailing complex syntheses using the amino group as templates and modern techniques focussing on the introduction of the amino group. A definitive must-have for every chemist.