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1. |
Record Nr. |
UNINA9910437992603321 |
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Titolo |
Advances in DNA repair in cancer therapy / / Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali, editors |
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Pubbl/distr/stampa |
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New York, : Springer, 2013 |
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ISBN |
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1-283-93366-7 |
1-4614-4741-0 |
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Edizione |
[1st ed. 2013.] |
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Descrizione fisica |
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1 online resource (316 p.) |
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Collana |
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Cancer drug discovery and development |
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Altri autori (Persone) |
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PanasciLawrence |
AloyzRaquel |
Alaoui-JamaliMoulay |
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Disciplina |
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616.99 |
616.99/4061 |
616.99406 |
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Soggetti |
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Cancer - Treatment - Genetic aspects |
DNA repair |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Preface -- Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs -- DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy? -- Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses -- The relationship between DNA-repair genes, cellular radiosensitivity and the response of tumors and normal tissues to radiotherapy -- Important Roles of ERCC1 in DNA Repair and Targeted Therapy -- The role of BRCA1 and BRCA2 in anticancer drug therapy -- DNA-PK in CLL Chemotherapy -- Poly(ADP) ribose polymerase at the interface of DNA damage signalling and DNA repair -- Cellular protection against the antitumor drug bleomycin -- ATR as a Therapeutic Target -- Telomeres, Telomerase and DNA Damage Response in Cancer Therapy -- RAD51 is a key protein of DNA repair and homologous recombination in humans -- Index. |
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Sommario/riassunto |
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This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The |
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DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling is examined. |
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2. |
Record Nr. |
UNINA9910144231203321 |
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Titolo |
European economy . Supplement A Recent economic trends / / Commission of the European Communities, Directorate-General for Economic and Financial Affairs |
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Pubbl/distr/stampa |
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[Luxembourg], : The Directorate-General, [1981]-©2001 |
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Descrizione fisica |
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Disciplina |
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Soggetti |
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Economic history |
Periodicals. |
European Economic Community countries Economic conditions Periodicals |
European Union countries Economic conditions Periodicals |
European Economic Community countries |
European Union countries |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Periodico |
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Note generali |
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