| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910144132603321 |
|
|
Autore |
Kubinyi Hugo |
|
|
Titolo |
QSAR : Hansch analysis and related approaches [[electronic resource] /] / by Hugo Kubinyi |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Weinheim ; ; New York, : VCH, c1993 |
|
|
|
|
|
|
|
ISBN |
|
1-281-75888-4 |
9786611758882 |
3-527-61682-9 |
3-527-61683-7 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (254 p.) |
|
|
|
|
|
|
Collana |
|
Methods and principles in medicinal chemistry ; ; v. 1 |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
|
|
Soggetti |
|
QSAR (Biochemistry) |
Pharmaceutical chemistry |
Electronic books. |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references (p. [183]-210) and index. |
|
|
|
|
|
|
Nota di contenuto |
|
QSAR: Hansch Analysis and Related Approaches; Content; 1. Introduction; 1.1. History and Development of QSAR; 1.2. Drug-Receptor Interactions; 2. Biological Data. The Additivity of Group Contributions; 3. Parameters; 3.1. Lipophilicity Parameters; 3.2. The Measurement of Partition Coefficients and Related Lipophilicity Parameters; 3.3. Lipophilicity Contributions and the Calculation of Partition Coefficients; 3.4. Polarizability Parameters; 3.5. Electronic Parameters; 3.6. Steric Parameters; 3.7. Other Parameters; 3.8. Indicator Variables; 4. Quantitative Models |
4.1. The Extrathermodynamic Approach (Hansch Analysis)4.2. The Additivity Model (Free Wilson Analysis); 4.3. The Relationships between Hansch and Free Wilson Analysis (The Mixed Approach); 4.4. Nonlinear Relationships; 4.5. Dissociation and Ionization of Acids and Bases; 4.6. Other QSAR Approaches; 5. Statistical Methods; 5.1. Regression Analysis; 5.2. The Significance and Validity of QSAR Regression Equations; 5.3. Partial Least Squares (PLS) Analysis and Other |
|
|
|
|
|
|
|
|
|
|
|
|
|
Multivariate Statistical Methods; 6. Design of Test Series in QSAR; 7. Applications of Hansch Analysis; 7.1. Enzyme Inhibition |
7.2. Other in vitro Data7.3. Pharmacokinetic Data; 7.4. Other Biological Data; 7.5. Activity-Activity Relationships; 8. Applications of Free Wilson Analysis and Related Models; 9. 3D QSAR Approaches; 9.1. Stereochemistry and Drug Action; 9.2. Active Site Interaction Models; 9.3. Comparative Molecular Field Analysis (CoMFA); 9.4. Molecular Similarity QSAR Analyses; 10. Summary and Conclusions; References; Index |
|
|
|
|
|
|
Sommario/riassunto |
|
Finding the new remedy for a certain disease: an inspired goal. QSAR, an invaluable tool in drug design, aids scientists to attain this aim.This book is a long-awaited comprehensive text to QSAR and related approaches. It provides a practice-oriented introduction to the theory, methods and analyses for QSAR relationships, including modelling-based and 3D approaches.Hugo Kubinyi is a leading expert in QSAR. Readers will benefit from the author's 20 years of practical experience, from his careful calculations and recalculations of thousands of QSAR equations. Among the topics cov |
|
|
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910783750603321 |
|
|
Autore |
Woolford Andrew John <1971-> |
|
|
Titolo |
Between justice and certainty : the British Columbia treaty process / / Andrew Woolford |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Vancouver : , : UBC Press, , 2005 |
|
©2005 |
|
|
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (ix, 229 pages) |
|
|
|
|
|
|
Collana |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Indians of North America - British Columbia |
Indians of North America - British Columbia - Government relations |
Indians of North America - Legal status, laws, etc - British Columbia |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Bibliographic Level Mode of Issuance: Monograph |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
|
|
|
|
|
Nota di contenuto |
|
Between the procedure and substance of justice The imposition of colonial visions of justice First nations justice frames The British Columbia treaty process Visions of justice Visions of certainty |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
"In Between Justice and Certainty, Andrew Woolford examines the interplay between Aboriginal and non-Aboriginal visions of justice and certainty in the first decade of the B.C. treaty process to determine whether there is a space between the two concepts in which modern treaties can be made." "Using interviews, field research, and both archival and modern treaty documents, Woolford argues that the goal of certainty is overriding the demand for justice, and suggests that greater attention to justice is necessary if we are to initiate a process of reconciliation between Aboriginal and non-Aboriginal peoples in British Columbia."--Jacket |
|
|
|
|
|
|
|
| |