|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910144116703321 |
|
|
Titolo |
Lipophilicity in drug action and toxicology [[electronic resource] /] / edited by Vladimir Pliška, Bernard Testa, and Han van de Waterbeemd |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Weinheim ; ; New York, : VCH, c1996 |
|
|
|
|
|
|
|
ISBN |
|
1-281-84266-4 |
9786611842666 |
3-527-61499-0 |
3-527-61498-2 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (466 p.) |
|
|
|
|
|
|
Collana |
|
Methods and principles in medicinal chemistry ; ; v. 4 |
|
|
|
|
|
|
Altri autori (Persone) |
|
PliškaVladimir |
TestaBernard |
WaterbeemdHan van de |
|
|
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
|
|
Soggetti |
|
Drug lipophilicity |
Toxicology |
Electronic books. |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Lipophilicity in Drug Action and Toxicology; Preface; A Personal Foreword; List of Contributors; Contents; 1 Lipophilicity : The Empirical Tool and the Fundamental Objective . An Introduction; 1.1 Setting the Scene; 1.2 Biological Aspects; 1.3 The Molecule in the Background; 1.4 Some Pragmatic Aspects; 1.4.1 Definitions and Symbols; 1.4.2 Experimental Techniques; 1.4.3 Computational Procedures; 1.5 Objectives of the Book; References; 2 Lipophilicity: A History; 2.1 Introduction; 2.2 Measurement of Lipophilicity; 2.3 Calculation of Lipophilicity; 2.3.1 Substitution Method |
2.3.2 Fragment Additivity Method2.3.3 Fragmentation into Atoms; 2.3.4 Molecular Orbital Calculations; 2.3.5 Calculations Based on Surface Area; 2.4 The Nature of Lipophilicity; 2.4.1 Relation to Other Molecular Properties; 2.4.2 Thermodynamics of Partitioning; 2.4.2.1 Phase Transfer; 2.4.2.2 The Aqueous Phase and the "Hydrophobic Bond"; 2.5 Lipophilicity and Biological Activity; References; 3 |
|
|
|
|