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Record Nr. |
UNINA9910144107803321 |
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Titolo |
Overcoming steroid insensitivity in respiratory disease [[electronic resource] /] / edited by Ian M. Adcock and Kian Fan Chung |
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Pubbl/distr/stampa |
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Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2008 |
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ISBN |
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1-281-84122-6 |
9786611841225 |
0-470-98573-9 |
0-470-98572-0 |
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Descrizione fisica |
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1 online resource (310 p.) |
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Altri autori (Persone) |
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AdcockIan (Ian M.) |
ChungK. Fan <1951-> |
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Disciplina |
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Soggetti |
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Respiratory organs - Diseases - Chemotherapy |
Steroid drugs |
Drug resistance |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Overcoming Steroid Insensitivity in Respiratory Disease; Contents; List of Contributors; Preface; 1 Molecular Mechanisms of Glucocorticoid Receptor Action; 1.1 Introduction; 1.2 Glucocorticoid Receptor; 1.3 Gene Induction by GR; 1.4 GR Transactivation and Histone Acetylation; 1.5 Post-translational Modifications of GR; 1.6 Repression of NF-κB-induced Inflammatory GeneExpression by GR-NF-κB; 1.7 GR-NF-κB Cross-talk; 1.8 Role of HDAC2 in Glucocorticoid Function; 1.9 Overexpression of HDAC2 Restores Glucocorticoid Sensitivity in Alveolar Macrophages |
1.10 Acetylation of hsp90 and Regulation of GR Function 1.11 Other Mechanisms of GR Action; 1.12 Conclusions; 2 Side Effects of Topical and Oral Glucocorticoids; 2.1 Introduction; 2.2 Glucocorticoid-induced Side Effects; 2.3 Summary; 3 Glucocorticoid Receptor Subtypes and Steroid Sensitivity; 3.1 Introduction; 3.2 Overview of Classic GR Function; 3.3 GR Subtypes Arising from Alternative Splicing; 3.4 GR Subtypes arising from Alternative Translation Initiation; 3.5 |
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