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1. |
Record Nr. |
UNINA9910144093303321 |
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Titolo |
Defining optimal immunotherapies for type 1 diabetes [[electronic resource] /] / [editors: Gregory Bock and Jamie Goode] |
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Pubbl/distr/stampa |
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London, : Novartis Foundation, 2008 |
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ISBN |
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1-281-84052-1 |
9786611840525 |
0-470-69740-7 |
0-470-69741-5 |
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Descrizione fisica |
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1 online resource (224 p.) |
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Collana |
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Novartis Foundation symposium ; ; v. 292 |
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Disciplina |
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Soggetti |
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Diabetes - Immunotherapy |
Diabetes - Treatment |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Defining Optimal Immunotherapies for Type 1 Diabetes; Contents; Participants; Chair's introduction; Pancreatic pathology in type 1 diabetes in human; The b cell population in type 1 diabetes; Bone marrow expressing a diabetes resistance MHC class II allele: diabetes deviation by chronic immune stimulation; Resuscitating adaptive Tregs with combination therapies?; Cytotoxic T cell mechanisms of b cell destruction in non-obese diabetic mice; Type 1 diabetes: chronic progressive autoimmune disease; Current and past prevention and intervention trials in type 1 diabetes |
CD8 and cytotoxic T cells in type 1 diabetesGeneral discussion I; General discussion II; Genetic and therapeutic control of diabetogenic CD8+ T cells; General discussion III; Towards a curative therapy in type 1 diabetes: remission of autoimmunity, maintenance and augmentation of b cell mass; Immune markers of disease and therapeutic intervention in type 1 diabetes; Re-establishing immune tolerance in type 1 diabetes via regulatory T cells; Translating mucosal antigen based prevention of autoimmune diabetes to human; Closing remarks; Contributor index; Subject index |
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Sommario/riassunto |
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This book is a comprehensive and up-to-date account of where we stand in immunological strategies for preventing or treating type 1 diabetes (T1D).Brings together contributions from the leaders in the arena of clinical immunotherapy, not limited to the diabetes field exclusively, in order to delineate a road-map that would lead to future clinical trials.The book integrates information from human and animal studies.The book considers T1D within the broader context of autoimmune disease.The format contains several discussions, which address specific questions and provides |
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2. |
Record Nr. |
UNINA9910495737503321 |
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Autore |
Ellison Nicolas |
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Titolo |
Semé sans compter : Appréhension de l'environnement et statut de l'économie en pays totonaque (Sierra de Puebla, Mexique) / Nicolas Ellison |
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Pubbl/distr/stampa |
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Paris, : Éditions de la Maison des sciences de l’homme, 2017 |
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ISBN |
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Descrizione fisica |
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1 online resource (464 p.) |
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Altri autori (Persone) |
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Soggetti |
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Sociology & Anthropology |
Mexique |
économie |
communauté |
environnement |
totonaque |
Sierra de Puebla |
café |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Les communautés totonaques de la Sierra de Puebla, dans le centre-est du Mexique, cultivent le café sous couvert forestier depuis la fin du |
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xixe siècle. À partir des années 1970, elles bénéficient de l'intervention de l'État mexicain qui les organise en coopératives de caféiculteurs avant de se retirer précipitamment à la fin des années 1980. En parallèle, les paysans totonaques n'ont jamais complètement abandonné la polyculture vivrière autour du maïs ni certains usages agroforestiers traditionnels en marge de la caféiculture. Nicolas Ellison a étudié les rapports pratiques et symboliques que les Totonaques de la Sierra de Puebla entretiennent avec leur environnement dans le contexte actuel des changements socio-économiques liés au développement et aux aléas de l'économie mexicaine et mondiale, notamment autour de la production de café. Il montre comment les dynamiques du développement et de l'économie de marché sont subordonnées aux normes locales du rapport aux autres et comment les représentations mésoaméricaines de l'environnement régissent les rapports pratiques à la nature. Cette étude s'adresse autant aux anthropologues désireux de comprendre comment les pratiques économiques et agricoles sont conditionnées par (en même temps qu'elles régissent) les rapports sociaux et les systèmes de savoir qu'aux socio-économistes soucieux d'une approche compréhensive des faits économiques, ainsi qu'à tous les lecteurs critiques du « développementalisme ». |
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3. |
Record Nr. |
UNINA9910831056303321 |
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Autore |
Heiberger Richard M. <1945-> |
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Titolo |
Computation for the analysis of designed experiments / / Richard M. Heiberger |
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Pubbl/distr/stampa |
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New York ; ; Chichester ; ; Brisbane : , : John Wiley & Sons, , 1989 |
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©1989 |
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ISBN |
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1-119-10287-1 |
1-119-10280-4 |
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Descrizione fisica |
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1 online resource (704 p.) |
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Collana |
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Wiley Series in Probability and Statistics |
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Disciplina |
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Soggetti |
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Mathematical statistics - Data processing |
Analysis of variance - Data processing |
Experimental design |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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""Front Cover""; ""Copyright Page""; ""Contents""; ""Preface""; ""Acknowledgments""; ""PART I COMPARATIVE STUDIES AND DESIGNED EXPERIMENTS""; ""1. Introduction""; ""1.1 Comparative Studies and Designed Experiments""; ""1.2 Programming Systems""; ""1.3 Least Squares and Analysis of Variance""; ""1.4 Interpretation of Design Specifications""; ""1.5 Analysis of Designed Experiments""; ""2. Simple Designed Experiments""; ""2.1 Principles of Designed Experiments""; ""2.1.1 Analysis of Designed Experiments""; ""2.1.2 Types of Simple Design""; ""2.2 The One-Way Design"" |
""2.2.1 Design Specification Statements""""2.2.2 Suppression of Redundant Notation""; ""2.2.3 The Experiment""; ""2.2.4 The Analysis""; ""2.3 The Blocked Design""; ""2.3.1 Consequences of Ignoring Blocks""; ""2.3.2 Specification of the Blocked Design""; ""2.3.3 The Experiment""; ""2.3.4 The Analysis""; ""2.3.5 An Alternative Design Specification""; ""2.3.6 Relative Efficiency of Blocking""; ""2.4 The Crossed Design""; ""2.4.1 Specification of the Crossed Design""; ""2.4.2 The Experiment""; ""2.4.3 The Analysis""; ""2.5 The Nested Design""; ""2.5.1 Specification of the Nested Design"" |
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""2.5.2 The Experiment""""2.5.3 The Analysis""; ""2.5.4 An Alternative Design Specification""; ""2.6 Comparison""; ""2.6.1 Inference""; ""2.6.2 Cost""; ""2.6.3 Specification""; ""2.7 Exercises""; ""PART II PROGRAMMING SYSTEMS""; ""3. User-level Considerations""; ""3.1 Program Behavior""; ""3.1.1 Batch Behavior of Programs""; ""3.1.2 Interactive Behavior of Programs""; ""3.2 User Documentation""; ""3.3 Aids to Interaction""; ""3.3.1 Error Handling""; ""3.3.2 Session Log""; ""3.3.3 Macros""; ""3.4 Input and Output Files""; ""3.5 Text Editors""; ""3.6 Testing of Programs"" |
""3.6.1 Random Input""""3.6.2 Standard Cases""; ""3.6.3 Boundary Conditions""; ""3.6.4 Pathological Example""; ""3.6.5 Numerical Stability""; ""3.7 Exercises""; ""4. Design of Individual Programs""; ""4.1 Programming Style""; ""4.1.1 Modular Programming""; ""4.1.2 Structured Programming""; ""4.1.3 Commented Code""; ""4.1.4 Choice of Algorithms""; ""4.1.5 Organization of Output on the Screen and Page""; ""4.2 Documentation""; ""4.2.1 User Documentation""; ""4.2.2 System Documentation""; ""4.2.3 Program Self-Documentation""; ""4.3 Host Language""; ""4.4 Exercises"" |
""5. Construction of Program Systems""""5.1 Programming Conventions""; ""5.2 Modularity""; ""5.3 Subroutine Communication""; ""5.3.1 Arguments""; ""5.3.2 Scope of Variable Definition""; ""5.3.3 Common Storage""; ""5.3.4 Files""; ""5.4 Programs Larger Than Available Computer Memory""; ""5.4.1 Overlay Structures""; ""5.4.2 Virtual Memory""; ""5.5 Portability""; ""5.5.1 Fortran""; ""5.5.2 BASIC""; ""5.5.3 APL""; ""5.5.4 C""; ""5.6 Extensibility""; ""5.6.1 Macro Facility""; ""5.6.2 Access to Computer Operating System""; ""5.6.3 Adding New Procedures""; ""5.7 Error Handling""; ""5.8 Maintenance"" |
""5.9 Exercises"" |
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Sommario/riassunto |
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Addresses the statistical, mathematical, and computational aspects of the construction of packages and analysis of variance (ANOVA) programs. Includes a disk at the back of the book that contains all program codes in four languages, APL, BASIC, C, and FORTRAN. Presents illustrations of the dual space geometry for all designs, including confounded designs. |
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