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Record Nr. |
UNINA9910144088103321 |
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Titolo |
Nuclear receptors in drug metabolism [[electronic resource] /] / edited by Wen Xie |
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Pubbl/distr/stampa |
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Hoboken, NJ, : John Wiley & Sons, c2009 |
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ISBN |
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1-281-93868-8 |
9786611938680 |
0-470-40910-X |
0-470-40905-3 |
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Descrizione fisica |
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1 online resource (362 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Drugs - Metabolism |
Nuclear receptors (Biochemistry) |
Genetic regulation |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Drug metabolism : significance and challenges -- Establishing orphan nuclear receptors PXR and CAR as xenobiotic receptors -- Nuclear receptor-mediated regulation of phase II conjugating enzymes -- Nuclear receptor-mediated regulation of drug transporters -- Structure and function of PXR and CAR -- Xenobiotic receptor cofactors and coregulators -- Animal models of xenobiotic nuclear receptors and their utility in drug development -- Nuclear receptors and drug-drug interactions of prescription drugs and herbal medicines -- Genetic variants of xenobiotic receptors and their implications in drug metabolism and pharmacogenetics -- Beyond PXR and CAR, regulation of xenobiotic metabolism by other nuclear receptors -- Emerging role of retinoid-related orphan receptor (ROR) and its cross talk with LXR (liver X receptor) in the regulation of drug-metabolizing enzymes. |
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Sommario/riassunto |
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This book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors |
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