1.

Record Nr.

UNINA9910144011803321

Titolo

Cell adhesion and human disease [[electronic resource] /] / [editors, Joan Marsh and Jamie A. Goode]

Pubbl/distr/stampa

Chichester ; ; New York, : Wiley, 1995

ISBN

1-282-12245-2

9786612122453

0-470-51471-X

0-470-51472-8

Descrizione fisica

1 online resource (256 p.)

Collana

Ciba Foundation symposium ; ; 189

Altri autori (Persone)

MarshJoan

GoodeJamie

Disciplina

611.01815

616.07

Soggetti

Cell adhesion

Cell adhesion molecules

Physiology, Pathological

Electronic books.

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

"Ciba Foundation"--Cover.

"Symposium on Cell adhesion and human disease, held at the Ciba Foundation, London 17-19 May 1994"--P. v.

Nota di bibliografia

Includes bibliographical references and indexes.

Nota di contenuto

CELL ADHESION AND HUMAN DISEASE; Contents; Participants; Chairman's introduction; P-selectin knockout: a mouse model for various human diseases; Creation and characterization of E-selectin- and VCAM-1 -deficient mice; Von Willebrand's disease and the mechanisms of platelet function; Leukocyte adhesion deficiency (LAD) II; Leukocyte and endothelial adhesion molecules in ischaemialreperfusion injuries; General discussion I; The integrin (VLA-4) as a therapeutic target; Adhesion molecules in cutaneous inflammation; Defective cell-cell adhesion in the epidermis

E-cadherin as an invasion suppressorThe role of CD44 splice variants in human metastatic cancer; Early metastasis of human solid tumours: expression of cell adhesion molecules; General discussion I I; Mechanisms fibronectin b i m p I icat ions of VCAM-1 and nding to or



integr rational drug design integrin CY& : n function and; General d iscussio n II; Treatment of inflammatory diseases with a monoclonal antibody to intercellular adhesion molecule 1; Identification of endogenous protein-associated carbohydrate ligands for E-selectin; Final discussion; Index of contributors; Subject index

Sommario/riassunto

Experts in their respective fields present papers concerned with the range of human diseases caused by defective or abnormal functioning of cell adhesion molecules. Discusses new therapeutic approaches to these maladies.