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1. |
Record Nr. |
UNINA9910143983503321 |
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Titolo |
Drug discovery and development . Volume 2 Drug development [[electronic resource] /] / edited by Mukund S. Chorghade |
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Pubbl/distr/stampa |
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Hoboken, N.J., : Wiley-Interscience, c2007 |
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ISBN |
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1-281-00213-5 |
9786611002138 |
0-470-08522-3 |
0-470-08521-5 |
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Descrizione fisica |
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1 online resource (401 p.) |
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Altri autori (Persone) |
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ChorghadeMukund S (Mukund Shankar) |
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Disciplina |
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Soggetti |
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Drug development |
Pharmacology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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DRUG DISCOVERY AND DEVELOPMENT; CONTENTS; Contributors; Preface; 17 Bioactive Molecules in Medicinal Plants: A Perspective on Their Therapeutic Action; 17.1 Introduction; 17.2 Evolutionary Relationships Among Plants and Humans; 17.3 Traditional Wisdom; 17.4 Unique Libraries for Plants; 17.5 Drugs and Bioactive Molecules from Plants; 17.6 Synergism in Herbal Formulations; 17.7 Interactions Between Modern Drugs and Natural Products; 17.8 Bioavailability and Bioefficacy Enhancers; 17.9 Combination Therapies in Modern Drugs; 17.10 Role of Developments in Technologies and Analytical Tools |
17.10.1 Developments in Separation Technologies17.10.2 Developments in Combined Techniques and Advanced Technologies; 17.10.3 Molecular Farming and Bioengineering of Medicinal Plants; 17.10.4 High-Throughput Screening of Natural Products; 17.11 Herbal Medicine: The Best Possible Route to Health Care; References; 18 Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools; 18.1 Introduction; 18.2 Solid-Supported Reagents as Tools in Natural Product Synthesis; 18.3 Multistep Use of Supported Reagents in Natural Product Synthesis; 18.4 |
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Conclusions |
References19 Insulin Sensitizers: Emerging Therapeutics; 19.1 Introduction; 19.2 Therapeutic Interventions; 19.3 Discovery of Insulin Sensitizers; 19.4 Journey Toward New Drugs; 19.5 Conclusions; References; 20 Criteria for Industrial Readiness of Chiral Catalysis Technology for the Synthesis of Pharmaceuticals; 20.1 Introduction; 20.2 Criteria for Technology Readiness; 20.3 Examples of Industrially Ready Chiral Catalytic Technologies and Their Application; 20.3.1 Lipase Bioresolution: Ethyl 3-Amino-3-Phenylpropionate; 20.3.2 Aminoacylase Bioresolution of N-Acylamino Acids |
20.3.3 Asymmetric Hydrogenation of Prochiral Olefins by Rhodium-DuPhos Catalysts20.3.4 Asymmetric Hydrogenation of Prochiral Ketones by Ruthenium-Biphosphine-Diamine Catalysts; 20.3.5 Asymmetric Hydroformylation with Rhodium-Phosphite Catalysts; 20.3.6 Asymmetric Allylic Substitution with Palladium-Based Catalysts; 20.4 How Industrially Ready Technology Can Deliver Commercial Advantages; 20.5 Conclusions; References; 21 Enantioselective Synthesis of Propargyl Alcohols as Multifunctional Synthons; 21.1 Introduction; 21.2 Asymmetric Reduction of Prochiral α, β-Alkynyl Ketones |
21.3 Addition of Acetylenic Anion to Carbonyl Carbon21.4 Desymmetrization and Enzymatic Strategies for Chiral Propargyl Alcohol Synthesis; 21.5 β-Elimination Strategy and Miscellaneous Approaches; 21.6 Conclusions; References; 22 Carbohydrates: From Chirons to Mimics; 22.1 Introduction; 22.2 Synthetic Strategies for C-Glycosides; 22.3 Synthetic Strategies for Carbon-Linked Disaccharides and Pseudosaccharides; References; 23 Meeting the Challenges of Process Development and Scale-up of Active Pharmaceutical Ingredients; 23.1 Introduction; 23.1.1 Drug Development in the Pharmaceutical Industry |
23.1.2 Challenges in Developing and Scaling Up Chemical Processes |
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Sommario/riassunto |
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From first principles to real-world applications-here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume re |
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2. |
Record Nr. |
UNINA9910713433903321 |
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Autore |
Stamey Timothy C. |
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Titolo |
Frequency and duration of flooding of Grove Creek near Kenansville, North Carolina, for present and proposed restored channel conditions / / by T.C. Stamey |
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Pubbl/distr/stampa |
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Raleigh, North Carolina : , : U.S. Geological Survey, , 1985 |
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Descrizione fisica |
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1 online resource (v, 52 pages) : illustrations, maps |
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Collana |
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Water-resources investigations report ; ; 85-4298 |
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Soggetti |
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Flood forecasting - North Carolina - Kenansville Region |
Floods - North Carolina - Kenansville Region |
River channels - North Carolina |
Flood forecasting |
Floods |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Prepared in cooperation with North Carolina Department of Human Resources." |
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Nota di bibliografia |
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Includes bibliographical references (pages 29). |
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3. |
Record Nr. |
UNINA9910792166103321 |
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Autore |
Freire Paulo <1921-1997.> |
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Titolo |
Pedagogy of Solidarity [[electronic resource]] |
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Pubbl/distr/stampa |
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Walnut Creek, : Left Coast Press, 2014 |
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ISBN |
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1-315-42280-8 |
1-315-42279-4 |
1-315-42281-6 |
1-61132-966-3 |
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Descrizione fisica |
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1 online resource (124 p.) |
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Collana |
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Qualitative Inquiry & Social Justice |
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Altri autori (Persone) |
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Araújo FreireAna María <1933-> |
OliveiraWalter Ferreira de |
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Disciplina |
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Soggetti |
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Community and school |
Critical pedagogy |
EDUCATION / Philosophy & Social Aspects |
POLITICAL SCIENCE / Political Freedom & Security / Human Rights |
Popular education |
SOCIAL SCIENCE / Methodology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di contenuto |
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Contents; Foreword - Memory's Hope: In the Shadow of Paulo Freire's Presence - Henry A. Giroux; Chapter 1. Introduction to Pedagogy of Solidarity - Walter Ferreira de Oliveira; Chapter 2. Pedagogy of Solidarity - Paulo Freire; Chapter 3. Pedagogy of Solidarity: A Dialogue - Paulo Freire; Chapter 4. For a Pedagogy of Solidarity - Walter Ferreira de Oliveira; Chapter 5. Testimony of Difference and the Right to Discuss Difference - Ana Maria Araújo Freire; Chapter 6. The Importance of Pedagogy of Solidarity - Norman K. Denzin; Afterword - Re-imaging Freire Beyond Methods - Donaldo Macedo; Index |
About the Authors |
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Sommario/riassunto |
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Famous Brazilian educational and social theorist Paulo Freire presents his ideas on the importance of community solidarity in moving toward social justice in schools and society. In a set of talks and interviews shortly before his death, Freire addresses issues not often highlighted |
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in his work, such as globalization, post-modern fatalism, and the qualities of educators for the 21st century. His illuminating comments are supplemented with commentaries by other well-known scholars, such as Ana Maria Araujo Freire, Norman Denzin, Henry Giroux, and Donaldo Macedo. |
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