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1. |
Record Nr. |
UNIBAS000036205 |
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Autore |
Goffis, Cesare Federico |
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Titolo |
Il canto I del Paradiso / Cesare Federico Goffis |
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Pubbl/distr/stampa |
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Firenze : Le Monnier, 1968 |
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Descrizione fisica |
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Collana |
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Disciplina |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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2. |
Record Nr. |
UNINA9910455258903321 |
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Autore |
Itō Mizuko |
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Titolo |
Engineering play [[electronic resource] ] : a cultural history of children's software / / Mizuko Ito |
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Pubbl/distr/stampa |
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Cambridge, Mass., : MIT Press, 2009 |
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ISBN |
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0-262-29155-X |
1-282-69456-1 |
9786612694561 |
0-262-25891-9 |
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Descrizione fisica |
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1 online resource (247 p.) |
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Collana |
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The John D. and Catherine T. MacArthur Foundation Series on Digital Media and Learning |
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Disciplina |
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Soggetti |
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Children's software - Development - United States - History |
Computer-assisted instruction - United States |
Computers and children - United States |
Entertainment computing - United States |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Contents; Series Foreword; Acknowledgments; 1 Introduction; 2 Academics; 3 Entertainment; 4 Construction; 5 Conclusion; Notes; References; Index |
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Sommario/riassunto |
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How the influential industry that produced such popular games as Oregon Trail and KidPix emerged from experimental efforts to use computers as tools in child-centered learning. |
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3. |
Record Nr. |
UNINA9910143740603321 |
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Titolo |
The hERG cardial potassium channel [[electronic resource] ] : structure, function, and long QT syndrome / / [editors, Derek J. Chadwick, James Goode] |
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Pubbl/distr/stampa |
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New York, : J. Wiley, 2005 |
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ISBN |
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1-280-27526-X |
9786610275267 |
0-470-02142-X |
0-470-02141-1 |
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Descrizione fisica |
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1 online resource (309 p.) |
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Collana |
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Novartis Foundation symposium ; ; 266 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Potassium channels |
Long QT syndrome |
Heart - Physiology |
Heart - Pathophysiology |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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THE hERG CARDIAC POTASSIUM CHANNEL: STRUCTURE, FUNCTION AND LONG QT SYNDROME; Contents; Participants; Chair's introduction; |
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Gating and assembly of heteromeric hERG1a/1b channels underlying I(Kr) in the heart; Discussion; Structure-function studies of the outer mouth and voltage sensor domain of hERG; Discussion; General discussion I; Voltage sensor movement in the hERGK(+) channel; Discussion; hERG channel trafficking; Discussion; Dynamic control of hERG/I(Kr) by PKA-mediated interactions with 14-3-3; Discussion; General discussion II |
Does hERG coassemble with a b subunit? Evidence for roles of MinK and MiRP1Discussion; hERG block, QT liability and sudden cardiac death; Discussion; Structural determinants for high-affinity block of hERG potassium channels; Discussion; Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs; Discussion; In silico modelling-pharmacophores and hERG channel models; Discussion; The long QTsyndrome: a clinical counterpart of HERG mutations; Discussion; Cellular mechanisms of Torsade de Pointes; Discussion |
Expression and role of hERG channels in cancer cellsDiscussion; TRIad: foundation for proarrhythmia (triangulation, reverse use dependence and instability); Discussion; Drug-induced QT interval prolongation: regulatory guidance and perspectives on hERG channel studies; Discussion; Closing remarks; Index of contributors; Subject index |
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Sommario/riassunto |
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This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding. It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. Better understanding of the role of the hERG channe |
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4. |
Record Nr. |
UNINA9910797430703321 |
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Autore |
Bailey John <1944 November 30-> |
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Titolo |
The politics of crime in Mexico : democratic governance in a security trap / / John Bailey |
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Pubbl/distr/stampa |
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Boulder, Colorado : , : FirstForumPress, a division of Lynne Rienner Publishers, Incorporated, , 2014 |
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ISBN |
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Descrizione fisica |
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1 online resource (247 p.) |
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Disciplina |
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Soggetti |
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Crime - Political aspects - Mexico |
Democracy - Mexico |
Internal security - Political aspects - Mexico |
Political corruption - Mexico |
Organized crime - Political aspects - Mexico |
Drug traffic - Political aspects - Mexico |
Criminal justice, Administration of - Mexico |
Mexico Politics and government 2000- |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Security traps and Mexico's democracy -- Foundational crime : tax evasion and informality -- Common crime and democracy : weakening vs. deepening -- Organized crime : theory and applications to kidnapping -- Drug trafficking organizations and democratic governance -- State responses to organized crime -- Escape routes : policy adaptation and diffusion. |
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Sommario/riassunto |
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What kind of democracy will emerge in Mexico when the current levels of violence are brought under control? Will democratic reformers gain strength in the new equilibrium between government and criminal organizations? Or will corruption tilt the balance toward criminal interests? In the context of these questions, John Bailey explores the "security trap" in which Mexico is currently caught—where the dynamics of crime, violence, and corruption conspire to override efforts to put the country on a path toward democratic governance. |
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5. |
Record Nr. |
UNIORUON00106393 |
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Autore |
FA'IQ, Nuru'l-din Husayn Xan Razvi |
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Titolo |
Maxzan-e Sha'ra ya'ni Tazkira Sha'ra'e Gujarat / Nuru'l-din Husayn Xan Razvi Fa'iq |
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Pubbl/distr/stampa |
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Edizione |
[Aurangabad Dakan : Anjuman-e Taraqqi-e Urdu] |
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Descrizione fisica |
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Altro frontespizio : Qazi Nuruddin Husain Khan Rizvi Faiq- Makhzan-i Shuara |
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Classificazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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