| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910465429503321 |
|
|
Titolo |
Aggressive breast cancer [[electronic resource] /] / Regina H. DeFrina, editor |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
New York, : Nova Science Publishers, c2010 |
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (276 p.) |
|
|
|
|
|
|
Collana |
|
Cancer etiology, diagnosis and treatments series |
|
|
|
|
|
|
Altri autori (Persone) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Breast - Cancer |
Breast - Diseases |
Electronic books. |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
""AGGRESSIVE BREAST CANCER ""; ""AGGRESSIVE BREAST CANCER ""; ""CONTENTS ""; ""PREFACE""; ""RESEARCH AND REVIEW ARTICLES""; ""THE HER2 ONCOGENE IN BREAST CANCER ""; ""ABSTRACT ""; ""INTRODUCTION ""; ""HER PROTEIN RECEPTORS: SIGNAL TRANSDUCTION AND ONCOGENESIS ""; ""Intracellular Signaling Pathways ""; ""HER-Induced Cell Cycle Progression and Survival Pathways ""; ""OVER EXPRESSION OF HER2 AND THE PROGNOSIS OF INVASIVE BREAST CANCER ""; ""HER2 as A Prognostic Factor: Node-Positive Versus Node-Negative Disease""; ""HER Status and Lymphoid Infiltration "" |
""HER2 and Progression of Early Breast Cancer Lesions to Invasive Carcinomas""""Relationship Between HER2 and Estrogen Receptor Expression ""; ""HER2 ABNORMALITIES IN OTHER TYPES OF BREAST MALIGNANCIES ""; ""HER2 ABNORMALITIES IN OTHER TYPES OF BREAST MALIGNANCIES ""; ""Evaluating HER2 in Breast Tissue ""; ""HER2 TARGETED THERAPY IN BREAST CANCER ""; ""The Role of Trastuzumab in HER2 Overexpressing Breast Cancer ""; ""The Role of Pertuzumab in HER2 Overexpressing Breast Cancer ""; ""The Role of Trastuzumab-DM1 in HER2 Overexpressing Breast Cancer "" |
""Inhibiting Several HER Receptors: The Role of Lapatinib in HER2 Overexpressing Breast Cancer """"Circulating Serum HER2 Levels ""; ""PROPOSED RESISTANCE TO ANTI-HER2 THERAPIES ""; ""Altered |
|
|
|
|
|
|
|
|
|
|
Receptor-Antibody Interaction ""; ""Increased Signaling from other Receptors of the HER Family ""; ""Increased Signaling from other Receptors Activating the MAPK and PI3K Pathways ""; ""Constitutive Activation of Downstream Effectors ""; ""HER2 OVEREXPRESSION AND CHEMOTHERAPY ""; ""Anthracyclines ""; ""Taxanes ""; ""HER2 OVEREXPRESSION AND HORMONAL THERAPY "" |
""CNS DISEASE IN HER2 OVEREXPRESSED BREAST CANCER """"CNS Metastases in Adjuvant Trials of Trastuzumab ""; ""Prognosis of CNS Metastases in HER2 Overexpressing Breast Cancer""; ""CONCLUSION ""; ""REFERENCES""; ""MULTI-DRUG RESISTANCE AS A PROBLEM CHALLENGING BREAST CANCER CHEMOTHERAPY ""; ""ABSTRACT ""; ""INTRODUCTION""; ""1) Non-Cellular MDR Mechanisms ""; ""2) Cellular MDR Mechanisms: ""; ""1. Changes in the intracellular accumulation and distribution of the drug ""; ""1a. Alteration of drug influx ""; ""1b. Alteration of drug efflux ""; ""NORMAL TISSUE DISTRIBUTION"" |
""PHYSIOLOGICAL FUNCTIONS OF P-GP """"PHARMACOLOGICAL FUNCTIONS OF P-GP ""; ""P-GP SUBSTRATES ""; ""2. Increase in Drug Detoxification ""; ""3. Alterations of Drug Targets ""; ""4. Increase in DNA Repair Mechanism ""; ""5. Changes in Key Genes Controlling Cell Proliferation ""; ""5a. Changes in genes responsible for cell cycle control ""; ""5b. Abrogation of apoptosis ""; ""6. Micro-Environmental Stress-Mediated Resistance of Solid Tumors ""; ""7. Cancer Cell Dormancy and Resistant Cancer Stem Cells ""; ""MODULATION OF MDR PHENOTYPE "" |
""I. Circumvention of Drug Resistance Induced by P-Gp Pump Protein "" |
|
|
|
|
|
|
|
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910143628703321 |
|
|
Titolo |
Combinatorial Pattern Matching : 11th Annual Symposium. CPM 2000, Montreal, Canada, June 21-23, 2000, Proceedings / / edited by Raffaele Giancarlo, David Sankoff |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2000 |
|
|
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Edizione |
[1st ed. 2000.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (XI, 426 p.) |
|
|
|
|
|
|
Collana |
|
Lecture Notes in Computer Science, , 0302-9743 ; ; 1848 |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Pattern perception |
Computers |
Algorithms |
Natural language processing (Computer science) |
Information storage and retrieval |
Combinatorial analysis |
Pattern Recognition |
Theory of Computation |
Algorithm Analysis and Problem Complexity |
Natural Language Processing (NLP) |
Information Storage and Retrieval |
Combinatorics |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Bibliographic Level Mode of Issuance: Monograph |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references at the end of each chapters and index. |
|
|
|
|
|
|
|
|
Nota di contenuto |
|
Invited Lectures -- Identifying and Filtering Near-Duplicate Documents -- Machine Learning for Efficient Natural-Language Processing -- Browsing around a Digital Library: Today and Tomorrow -- Summer School Lectures -- Algorithmic Aspects of Speech Recognition: A Synopsis -- Some Results on Flexible-Pattern Discovery -- Contributed Papers -- Explaining and Controlling Ambiguity in Dynamic Programming -- A Dynamic Edit Distance Table -- Parametric Multiple Sequence Alignment and Phylogeny Construction -- Tsukuba BB: A Branch and Bound Algorithm for Local Multiple Sequence Alignment -- |
|
|
|
|
|
|
|
|
|
|
|
A Polynomial Time Approximation Scheme for the Closest Substring Problem -- Approximation Algorithms for Hamming Clustering Problems -- Approximating the Maximum Isomorphic Agreement Subtree Is Hard -- A Faster and Unifying Algorithm for Comparing Trees -- Incomplete Directed Perfect Phylogeny -- The Longest Common Subsequence Problem for Arc-Annotated Sequences -- Boyer—Moore String Matching over Ziv-Lempel Compressed Text -- A Boyer—Moore Type Algorithm for Compressed Pattern Matching -- Approximate String Matching over Ziv—Lempel Compressed Text -- Improving Static Compression Schemes by Alphabet Extension -- Genome Rearrangement by Reversals and Insertions/Deletions of Contiguous Segments -- A Lower Bound for the Breakpoint Phylogeny Problem -- Structural Properties and Tractability Results for Linear Synteny -- Shift Error Detection in Standardized Exams -- An Upper Bound for Number of Contacts in the HP-Model on the Face-Centered-Cubic Lattice (FCC) -- The Combinatorial Partitioning Method -- Compact Suffix Array -- Linear Bidirectional On-Line Construction of Affix Trees -- Using Suffix Trees for Gapped Motif Discovery -- Indexing Text with Approximate q-Grams -- Simple Optimal String Matching Algorithm -- Exact and Efficient Computation of the Expected Number of Missing and Common Words in Random Texts -- Periods and Quasiperiods Characterization -- Finding Maximal Quasiperiodicities in Strings -- On the Complexity of Determining the Period of a String. |
|
|
|
|
|
|
Sommario/riassunto |
|
This book constitutes the refereed proceedings of the 11th Annual Symposium on Combinatorial Pattern Matching, CPM 2000, held in Montreal, Canada, in June 2000.The 29 revised full papers presented together with 3 invited contributions and 2 tutorial lectures were carefully reviewed and selected from 44 submissions. The papers are devoted to current theoretical and algorithmic issues of searching and matching strings and more complicated patterns such as trees, regular expression graphs, point sets and arrays as well as to advanced applications of CPM in areas such as Internet, computational biology, multimedia systems, information retrieval, data compression, and pattern recognition. |
|
|
|
|
|
|
|
| |