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Record Nr. |
UNINA9910143578003321 |
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Titolo |
Pharmacometrics : the science of quantitative pharmacology / / edited by Ene I. Ette, Anoixis Corporation, Paul J. Williams, University of the Pacific and Anoixis Corporation |
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Pubbl/distr/stampa |
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Hoboken, New Jersey : , : Wiley-Interscience, , [2007] |
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©2007 |
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ISBN |
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1-118-67951-2 |
1-280-82698-3 |
9786610826988 |
0-470-08797-8 |
0-470-08796-X |
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Descrizione fisica |
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1 online resource (1227 p.) |
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Classificazione |
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Disciplina |
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Soggetti |
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Pharmacology |
Pharmacokinetics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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PHARMACOMETRICS; CONTENTS; CONTRIBUTORS; PREFACE; ACKNOWLEDGMENTS; 1. Pharmacometrics: Impacting Drug Development and Pharmacotherapy; PART I GENERAL PRINCIPLES; 2. General Principles of Programming: Computer and Statistical; 3. Validation of Software for Pharmacometric Analysis; 4. Linear, Generalized Linear, and Nonlinear Mixed Effects Models; 5. Bayesian Hierarchical Modeling with Markov Chain Monte Carlo Methods; 6. Estimating the Dynamics of Drug Regimen Compliance; 7. Graphical Displays for Modeling Population Data; 8. The Epistemology of Pharmacometrics; 9. Data Imputation |
PART II POPULATION PHARMACOKINETIC BASIS OF PHARMACOMETRICS10. Population Pharmacokinetic Estimation Methods; 11. Timing and Efficiency in Population Pharmacokinetic/Pharmacodynamic Data Analysis Projects; 12. Designing Population Pharmacokinetic Studies for Efficient Parameter |
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Estimation; 13. Population Models for Drug Absorption and Enterohepatic Recycling; 14. Pharmacometric Knowledge Discovery from Clinical Trial Data Sets; 15. Resampling Techniques and Their Application to Pharmacometrics; 16. Population Modeling Approach in Bioequivalence Assessment |
PART III PHARMACOKINETICS / PHARMACODYNAMICS RELATIONSHIP: BIOMARKERS AND PHARMACOGENOMICS, PK/PD MODELS FOR CONTINUOUS DATA, AND PK/PD MODELS FOR OUTCOMES DATA17. Biomarkers in Drug Development and Pharmacometric Modeling; 18. Analysis of Gene Expression Data; 19. Pharmacogenomics and Pharmacokinetic/Pharmacodynamic Modeling; 20. Empirical Pharmacokinetic/Pharmacodynamic Models; 21. Developing Models of Disease Progression; 22. Mechanistic Pharmacokinetic/Pharmacodynamic Models I; 23. Mechanistic Pharmacokinetic/Pharmacodynamic Models II; 24. PK/PD Analysis of Binary (Logistic) Outcome Data |
25. Population Pharmacokinetic/Pharmacodynamic Modeling of Ordered Categorical Longitudinal Data26. Transition Models in Pharmacodynamics; 27. Mixed Effects Modeling Analysis of Count Data; 28. Mixture Modeling with NONMEM V; PART IV CLINICAL TRIAL DESIGNS; 29. Designs for First-Time-in-Human Studies in Nononcology Indications; 30. Design of Phase 1 Studies in Oncology; 31. Design and Analysis of Clinical Exposure: Response Trials; PART V PHARMACOMETRIC KNOWLEDGE CREATION; 32. Pharmacometric/Pharmacodynamic Knowledge Creation: Toward Characterizing an Unexplored Region of the Response Surface |
33. Clinical Trial Simulation: Theory34. Modeling and Simulation: Planning and Execution; 35. Clinical Trial Simulation: Efficacy Trials; PART VI PHARMACOMETRIC SERVICE AND COMMUNICATION; 36. Engineering a Pharmacometrics Enterprise; 37. Communicating Pharmacometric Analysis Outcome; PART VII SPECIFIC APPLICATION EXAMPLES; 38. Pharmacometrics Applications in Population Exposure-Response Data for New Drug Development and Evaluation; 39. Pharmacometrics in Pharmacotherapy and Drug Development: Pediatric Application |
40. Pharmacometric Methods for Assessing Drug-Induced QT and QTc Prolongations for Non-antiarrhythmic Drugs |
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Sommario/riassunto |
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Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of pharmac |
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