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1. |
Record Nr. |
UNINA9910451265103321 |
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Titolo |
Structural and functional organization of the synapse [[electronic resource] /] / edited by Johannes W. Hell and Michael D. Ehlers |
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Pubbl/distr/stampa |
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New York, : Springer, c2008 |
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ISBN |
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1-281-51249-4 |
9786611512491 |
0-387-77232-4 |
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Edizione |
[1st ed. 2008.] |
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Descrizione fisica |
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1 online resource (814 p.) |
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Altri autori (Persone) |
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EhlersMichael D |
HellJohannes W |
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Disciplina |
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Soggetti |
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Neural transmission |
Synapses |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Diversity in Synapse Structure and Composition -- The Role of Glutamate Transporters in Synaptic Transmission -- Structure and Function of Vertebrate and Invertebrate Active Zones -- Neurotransmitter Release Machinery: Components of the Neuronal SNARE Complex and Their Function -- The Molecular Machinery for Synaptic Vesicle Endocytosis -- Initiation and Regulation of Synaptic Transmission by Presynaptic Calcium Channel Signaling Complexes -- Adhesion Molecules at the Synapse -- Dendritic Organelles for Postsynaptic Trafficking -- Structure and Mechanism of Action of AMPA and Kainate Receptors -- Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity -- Structure and Function of the NMDA Receptor -- Molecular Properties and Cell Biology of the NMDA Receptor -- Surface Trafficking of Membrane Proteins at Excitatory and Inhibitory Synapses -- Scaffold Proteins in the Postsynaptic Density -- Ca2+ Signaling in Dendritic Spines -- Postsynaptic Targeting of Protein Kinases and Phosphatases -- Long-Term Potentiation -- Homeostatic Synaptic Plasticity -- Ubiquitin and Protein Degradation in Synapse Function -- Signaling from Synapse to Nucleus -- Molecular |
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Organization of the Postsynaptic Membrane at Inhibitory Synapses -- Acid-Sensing Ion Channels (ASICs) and pH in Synapse Physiology -- Glia as Active Participants in the Development and Function of Synapses -- Plasticity of Dentate Granule Cell Mossy Fiber Synapses: A Putative Mechanism of Limbic Epileptogenesis -- Stroke – A Synaptic Perspective -- and Pathological Pain. |
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Sommario/riassunto |
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Synapses play a central role in the brain by mediating signal transmission between neurons. This book provides a fundamental description of the synapse by leading experts in the field. Each individual synapse carries out its numerous functions in a tiny space, thereby requiring an exquisite molecular and functional arrangement. This book describes the molecular structure and cellular function of central synapses in the brain, providing a detailed view of the brain’s fundamental unit of information storage. |
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2. |
Record Nr. |
UNINA9910143565603321 |
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Autore |
Sharpe Neil F |
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Titolo |
Genetic testing [[electronic resource] ] : care, consent, and liability / / Neil F. Sharpe, Ronald F. Carter |
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Pubbl/distr/stampa |
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Hoboken, N.J., : Wiley-Liss, c2006 |
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ISBN |
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1-280-28812-4 |
9786610288120 |
0-470-36082-8 |
0-471-74889-7 |
0-471-74888-9 |
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Descrizione fisica |
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1 online resource (622 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Human chromosome abnormalities |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references (p. 453-566) and index. |
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Nota di contenuto |
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Genetic Testing; Contents; Contributors; Foreword; 1 Genetic |
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Counseling and the Physician-Patient Relationship; Overview; Introduction; Core Concepts; Trust, Genetic Testing, and the Physician-Patient Relationship; Genetic Counseling and the Physician-Patient Relationship; Nondirectiveness; Web Resources; Genetic Counseling Approach to Genetic Testing; Introduction to Genetic Counseling; Historical Perspective and the Role of Nondirectiveness in Genetic Counseling; Practice of Genetic Counseling Today; Genetic Counselor Goals; Important Cultural Considerations in Genetic Counseling |
Factors That Promote Effective Genetic CounselingGenetics in Mainstream Medical Care: The Emerging Milieu; Categories of Genetic Testing: Issues to Consider; Summary; 2 Communication; Overview; Need To Know; Standards; Watch Out For; Obligations; Methods; Terms, Tone, and Follow-up; Culture and Communication in the Realm of Fetal Diagnosis: Unique Considerations for Latino Patients; Miscommunication and Prenatal Genetic Care; Idioms and Jargon; Suggestions; Cultural Sensitivity; Genetic Consultation; Opportunistic Observation; Translation and Second-Hand Information; On-Site Translators |
Genetic ConsultationInterview after Consultation; Family and Friends as Translators; Confidence and Trust; Woman Who Declined Amniocentesis; Woman Who Accepted Amniocentesis; Discussion: Communication, Miscommunication, and Genetic Counseling; Conclusion; Communication: Clinical Diagnosis; History; Background and Diagnostic Criteria for NF1; Molecular Genetics; Issues; Introduction; Client Characteristics: Culture and Intellect; Educational Tools and Facilitators; Decision Making: Considerations and Approaches; 3 Psychological Aspects; Overview; Introduction; Scenario 1; Scenario 2 |
Need to KnowPotential for Psychological Harm; Potential for Psychological Benefit; Anxiety and Perceived Risk: Pretest Status of Patient; Recognizing Psychological Stress; Coping with Stress Induced by Genetic Counseling and Testing; Watch Out For; Factors Affecting Perception; Standards and Interpretation; Psychological Aspects of Genetic Testing For Adult-Onset Hereditary Disorders; Introduction; Process of Genetic Testing; Pretest Genetic Counseling Phase; Posttest Counseling Phase: Disclosure of the Genetic Test Result; Test Result Indicating Presence of Genetic Mutation |
Negative Test Result Indicating Absence of Genetic MutationReceiving an Ambiguous Genetic Test Result; Impact of Genetic Testing on the Family; Societal and Ethical Issues Linked to Psychosocial Outcomes; Clinical Implications; Summary; 4 Duty of Care; Overview; Need to Know; Standard of Care; Watch Out For; Duty of Care; 5 Family History; Overview; Introduction; Clinical Scenario; Need to Know; Family Pedigree; Watch Out For; Inaccurate or Incomplete Information; Prenatal and Neonatal Testing; Family History in Adult-Onset Disorders |
Importance of Family History in Approaches to Common Chronic Diseases of Adulthood |
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Sommario/riassunto |
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A complete review of the issues with specific recommendations and guidelines.With over 1,000 tests commercially available, genetic testing is revolutionizing medicine. Health care professionals diagnosing and treating patients today must consider genetic factors, the risks and limitations of genetic testing, and the relevant law. Genetic Testing: Care, Consent, and Liability offers the only complete, practical treatment of the genetic, clinical, ethical, and legal issue surrounding genetic testing. The authors present protocols, policies, and models of care that are currently in use, a |
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3. |
Record Nr. |
UNINA9911020970903321 |
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Autore |
Schipa, Michelangelo |
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Titolo |
Il Regno di Napoli al tempo di Carlo di Borbone : opera premiata dalla R. Accademia delle Scienze Morali e Politiche di Napoli Col. Premio Quinquennale di Lire Quattromila (1902) / Michelangelo Schipa |
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Pubbl/distr/stampa |
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London, : Forgotten Books, 2018 |
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ISBN |
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Descrizione fisica |
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Locazione |
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Collocazione |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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