| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910142493503321 |
|
|
Titolo |
On-line LC-NMR and related techniques [[electronic resource] /] / edited by Klaus Albert |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
New York, : J. Wiley & Sons, c2002 |
|
|
|
|
|
|
|
ISBN |
|
1-280-27011-X |
9786610270118 |
0-470-31452-4 |
0-470-85481-2 |
0-470-85482-0 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (308 p.) |
|
|
|
|
|
|
Altri autori (Persone) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
|
|
Soggetti |
|
Nuclear magnetic resonance spectroscopy |
Liquid chromatography |
Electronic books. |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
On-Line LC-NMR and Related Techniques; Contents; Contributors; Preface; 1 LC-NMR: Theory and Experiment; 1.1 Introduction; 1.2 NMR in a Flowing Liquid; 1.3 Design of Continuous-Flow NMR Probes; 1.4 Experimental Arrangement for HPLC-(1)H NMR Coupling; 1.5 Practical Considerations, Solvent Suppression Techniques, Gradient Elution and Purity of HPLC Solvents; 1.5.1 Solvent Signal Suppression; 1.5.2 Purity of HPLC-Grade Solvents; References; 2 LC-NMR: Automation; 2.1 Practical Use of LC-NMR and LC-NMR/MS; 2.2 Different Working Modes in LC-NMR; 2.2.1 On-Flow; 2.2.2 Direct Stop-Flow |
2.2.3 Loop Storage/Loop Transfer2.2.4 Conclusions; 2.3 Use of Mass Spectrometry in the Set-Up; 2.4 Measurement Procedures; 2.4.1 Sample Preparation and Introduction ('Injection') into the Chromatography System; 2.4.2 Chromatographic Separation; 2.4.3 Peak Detection and Selection; 2.4.4 Mass Spectrometric Measurements; 2.4.5 Nuclear Magnetic Resonance Measurements; 2.4.6 Sample Recovery; 2.5 Conclusions; References; 3 Biomedical and Pharmaceutical Applications |
|
|
|
|
|
|
|
|
|
|
|
of HPLC-NMR and HPLC-NMR-MS; 3.1 Introduction; 3.2 Technical and Operational Overview; 3.3 Applications in Combinatorial Chemistry |
3.4 Application to Chemical Impurities3.5 Application to Chiral Separations of Pharmaceutical Mixtures; 3.6 Application to Natural Products; 3.7 Application to Chemical Reactivity of Drug Glucuronides; 3.8 Application to Futile Deacetylation Reactions; 3.9 Application to Trapping of Reactive Intermediates; 3.10 Application to Uptake and Transformation of Xenobiotics by Plants; 3.11 Separation of Lipoproteins and their Characterisation using HPLC-NMR; 3.12 Superheated-Water HPLC-NMR and HPLC-NMR-MS Studies on Pharmaceuticals |
3.13 Application of Hypernation to a Mixture of Non-Steroidal Anti-Inflammatory Drugs3.14 Concluding Remarks; References; 4 Application of On-Line LC-NMR and Related Techniques to Drug Metabolism Studies; 4.1 Introduction; 4.2 LC-NMR Techniques; 4.2.1 Continuous-Flow LC-NMR; 4.2.2 Time-Slice LC-NMR; 4.2.3 Stop-Flow LC-NMR; 4.2.4 Loop-Storage; 4.2.5 LC-NMR-MS; 4.3 Application of LC-NMR-MS to Drug Metabolism: The Structure Elucidation of Rat Urinary Metabolites of Efavirenz by LC-NMR-MS; 4.3.1 Experimental; 4.3.2 Results; 4.4 Conclusions; References; 5 LC-NMR for Natural Products Analysis |
5.1 Application of LC-NMR and LC-NMR-MS Hyphenation to Natural Products Analysis5.1.1 Introduction; 5.1.1.1 General Aspects; 5.1.1.2 Applications; 5.1.2 Application of LC-NMR-MS to Glycosidic Natural Products of Marine Origin; 5.1.2.1 Introduction - Need for LC-NMR; 5.1.2.2 Methodology: On-Flow LC-NMR-MS Screening; 5.1.2.3 NMR - Structural Information; 5.1.2.4 Mass Spectrometry and D-H Back-Exchange Experiments; 5.1.2.5 Stop-Flow Experiments; 5.1.2.6 Complimentary Structural Information of NMR and MS; 5.1.2.7 Conclusions; 5.1.3 Acknowledgements; References |
5.2 Hyphenation of Modern Extraction Techniques to LC-NMR for the Analysis of Geometrical Carotenoid Isomers in Functional Food and Biological Tissues |
|
|
|
|
|
|
Sommario/riassunto |
|
This book gives a comprehensive overview of the basis and the current applications of LC-NMR and related techniques. It deals with the practical aspects of the hardware and software set-up for a successful performance of on-line coupling experiments. It covers the solution of real-word problems from the fields of biomedical, pharmaceutical and environmental studies as well as the analysis of natural products and polymeric compounds. Thus guidelines for an efficient application of the powerful hyphenated technique LC-NMR in combination with LC-MS are presented. Besides LC-NMR, important techniq |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910143561403321 |
|
|
Autore |
Harper Stephen C |
|
|
Titolo |
Extraordinary entrepreneurship [[electronic resource] ] : the professional's guide to starting an exceptional enterprise / / Stephen C. Harper |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Hoboken, N.J., : Wiley, c2005 |
|
|
|
|
|
|
|
ISBN |
|
1-119-19799-6 |
1-280-72224-X |
9786610722242 |
0-470-08727-7 |
0-471-70601-9 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (500 p.) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
|
|
Soggetti |
|
New business enterprises |
Entrepreneurship |
Electronic books. |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Introduction : the nature of entrepreneurship -- Essential entrepreneurial qualities and capabilities -- What type of venture do you have in mind? -- Identifying new venture opportunities -- Ventures that capitalized on market gaps -- Evaluating new venture opportunities -- Developing the business plan -- Components of the business plan -- Sources of funding -- Debt financing -- Seeking investors -- Going the angel route -- Venture capital funding -- Initial public offering -- Epilogue : entrepreneurial do's and don'ts. |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
The 21st Century brings all new rules. Entrepreneurs are challenging conventional wisdom and thinking outside the box. One of the first challenges involves challenging the assumption that a business has to be big to be successful. While most of the 20th century heralded big businesses, it is clear that businesses no longer have to be big to do big business. Now it is possible for a handful of people to operate a global business from virtually any place on the planet. Today, the |
|
|
|
|
|
|
|
|
|
|
keyboard has overtaken the boardroom. Financial markets, alliances, and joint ventures have eliminated the need for e |
|
|
|
|
|
| |