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Record Nr. |
UNINA9910143512403321 |
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Titolo |
Neural transplantation in neurodegenerative disease [[electronic resource] ] : current status and new directions / / [editors Derek J. Chadwick and Jamie A. Goode] |
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Pubbl/distr/stampa |
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Chichester ; ; New York, : Wiley, 2000 |
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ISBN |
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1-280-27263-5 |
9786610272631 |
0-470-66829-6 |
0-470-87082-6 |
0-470-87083-4 |
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Descrizione fisica |
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1 online resource (335 p.) |
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Collana |
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Novartis Foundation symposium ; ; 231 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Nerve tissue - Transplantation |
Central nervous system - Transplantation |
Nervous system - Degeneration |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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NEURAL TRANSPLANTATION IN NEURODEGENERATIVE DISEASE: CURRENT STATUS AND NEW DIRECTIONS; Contents; Participants; Introduction; Cell replacement strategies for neurodegenerative disorders; Discussion; Functional analysis of fronto-striatal reconstruction by striatal grafts; Discussion; Functional reconstruction of the hippocampus: fetal versus conditionally immortal neuroepithelial stem cell grafts; Discussion; Gene transfer for neuroprotection in animal models of Parkinson's disease and amyotrophic lateral sclerosis; Discussion |
Repair of corticospinal axons by transplantation of olfactory ensheathing cellsDiscussion; Neural transplantation in Parkinson's disease; Discussion; Transplantation of human fetal striatal tissue in |
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Huntington's disease: rationale for clinical studies; Discussion; General discussion I Prospects for fetal transplants; Neurotransplantation in neurodegenerative disease: a survey of relevant issues in developmental neurobiology; Discussion; Molecular and cellular mechanisms in immune rejection of intracerebral neural transplants; Discussion; Porcine neural xenografts: what are the issues? |
DiscussionGene transfer techniques for the delivery of GDNF in Parkinson's disease; Discussion; Neurogenesis in the adult hippocampus; Discussion; Neural stem cells are uniquely suited for cell replacement and gene therapy in the CNS; Discussion; Functional repair with neural stem cells; Discussion; Remyelinating the demyelinated CNS; Discussion; General discussion II The ES cell approach; Final discussion The future for fetal grafts; Stem cell strategies; Index of contributors; Subject index |
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Sommario/riassunto |
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The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches to fetal transplantation being developed. This timely book brings together leading neuroscientists, clinicians, and cell and developmental biologists to discuss the use of neural transplants in neurodegenerative disorders, such as Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential a |
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2. |
Record Nr. |
UNINA9910483830103321 |
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Autore |
Weiss Jeffrey N. |
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Titolo |
Neurologic stem cell surgery / / Jeffrey N. Weiss |
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Pubbl/distr/stampa |
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Cham, Switzerland : , : Springer, , [2021] |
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©2021 |
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ISBN |
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Edizione |
[1st ed. 2021.] |
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Descrizione fisica |
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1 online resource (XI, 119 p. 5 illus., 4 illus. in color.) |
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Disciplina |
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Soggetti |
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Stem cells - Therapeutic use |
Cèl·lules mare |
Neurocirurgia |
Teràpia cel·lular |
Llibres electrònics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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1. Study Protocols and Informed Consent -- 2. Procedure - Additional Patient Explanation -- 3. Some Thoughts -- 4. Other Treatment Modalities. |
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Sommario/riassunto |
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This is a concise how-to of successfully treating previously poorly or untreatable neurologic conditions with stem cell therapies. The text examines the IRB approved protocols of NEST (Neurologic Bone Marrow Derived Stem Cell Treatment Study), SCiExVr (Stem Cell Spinal Cord Injury Exoskeleton and Virtual Reality Treatment Study), and ACIST (Alzheimer’s and Cognitive Impairment Stem Cell Treatment Study). The discussion focuses on the protocols and informed consents and may be used as a template for specialists to develop clinical trials utilizing stem cell based therapy. Other potential noninvasive treatments for brain injury are also discussed. Neurologic Stem Cell Surgery, the sister text to the recently published Retinal and Optic Nerve Stem Cell Surgery, is an invaluable reference for all physicians with an interest in the development of stem cell based treatments. |
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