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1. |
Record Nr. |
UNINA9910143510703321 |
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Autore |
Senn Stephen |
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Titolo |
Cross-over trials in clinical research [[electronic resource] /] / Stephen Senn |
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Pubbl/distr/stampa |
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Chichester ; ; Hoboken, NJ, : J. Wiley, c2002 |
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ISBN |
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1-280-27006-3 |
9786610270064 |
0-470-35829-7 |
0-470-85458-8 |
0-470-85459-6 |
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Edizione |
[2nd ed.] |
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Descrizione fisica |
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1 online resource (363 p.) |
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Collana |
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Disciplina |
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Soggetti |
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Crossover trials |
Clinical trials |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references (p. 323-334) and indexes. |
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Nota di contenuto |
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Cross-over Trials in Clinical Research; Contents; Preface to the second edition; Preface to the first edition; 1 Introduction; 1.1 The purpose of this chapter; 1.2 An example; 1.3 Why are cross-over trials performed?; 1.4 What are the disadvantages of cross-over trials?; 1.5 Where are cross-over trials useful?; 1.6 What attitude to cross-over trials will be adopted in this book?; 1.7 Carry-over; 1.8 What may be done about carry-over?; 1.9 Other attitudes to be adopted; 1.10 Where else can one find out about cross-over trials? |
2 Some basic considerations concerning estimation in clinical trials*2.1 The purpose of this chapter; 2.2 Assumed background knowledge; 2.3 Control in clinical trials; 2.4 Two purposes of estimation; 2.5 Some features of estimation; 2.6 Practical consequences for cross-over trials; 3 The AB/BA design with Normal data; 3.1 An example; 3.2 A simple analysis ignoring the effect of period; 3.3 Student's approach*; 3.4 Assumptions in the matched-pairs t approach; 3.5 Adjusting for a period effect: two-sample t approach; 3.6 Adjusting for a period effect: |
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the Hills-Armitage approach |
3.7 Examining period effects3.8 Testing for carry-over and/or treatment by period interaction*; 3.9 A model for the AB/BA cross-over*; 3.10 Carry-over or treatment by period interaction?*; 3.11 Confidence intervals for carry-over*; 3.12 Are unbiased estimators of the treatment effect available?*; 3.13 Can we adjust for carry-over?*; 3.14 The two-stage analysis*; 3.15 Correcting the two-stage procedure*; 3.16 Use of baseline measurements; 3.17 A Bayesian approach; 3.18 Computer analysis; 3.19 Further reading; 3.20 Recommendations; Appendix 3.1 Analysis with GenStat® |
Appendix 3.2 Analysis with S-Plus®4 Other outcomes and the AB/BA design; 4.1 Introduction; 4.2 Transformations; 4.3 Non-parametric methods; 4.4 Binary outcomes; 4.5 Ordered categorical data; 4.6 Frequency data; 4.7 'Survival' data*; 4.8 Final remarks; Appendix 4.1 Analysis with GenStat®; Appendix 4.2 Analysis with S-Plus®; 5 Normal data from designs with three or more treatments; 5.1 Why do we have designs with three or more treatments?; 5.2 Sequences for trials with three or more treatments; 5.3 Analyses ignoring the effect of period; 5.4 Allowing for period effects |
5.5 Other miscellaneous issues5.6 Recommendations; Appendix 5.1 Analysis with GenStat®; Appendix 5.2 Analysis with S-Plus®; 6 Other outcomes from designs with three or more treatments; 6.1 Introduction; 6.2 Analyses which take no account of period effects; 6.3 Non-parametric analyses adjusting for period effects; 6.4 Hodges-Lehmann type estimators*; 6.5 A stratified period adjusted sign test; 6.6 Binary data; 6.7 Other analyses; Appendix 6.1 Analysis with GenStat®; Appendix 6.2 Analysis with S-Plus®; 7 Some special designs; 7.1 The scope of this chapter; 7.2 Factorial designs |
7.3 Incomplete block designs |
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Sommario/riassunto |
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Cross-over trials are an important class of design used in the pharmaceutical industry and medical research, and their use continues to grow. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials. It includes more background material, greater coverage of important statistical techniques, including Bayesian methods, and discussion of analysis using a number of statistical software packages.* Comprehensive coverage of the design and analysis of cross-over trials.* Each techn |
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2. |
Record Nr. |
UNINA9910830980703321 |
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Autore |
Aroca Ricardo |
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Titolo |
Surface enhanced vibrational spectroscopy [[electronic resource] /] / Ricardo Aroca |
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Pubbl/distr/stampa |
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Hoboken, NJ, : Wiley, 2006 |
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ISBN |
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1-280-44903-9 |
9786610449033 |
0-470-03564-1 |
0-470-03565-X |
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Descrizione fisica |
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1 online resource (261 p.) |
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Disciplina |
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Soggetti |
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Vibrational spectra |
Molecular spectroscopy |
Raman effect, Surface enhanced |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Theory of molecular vibrations, the origin of infrared and Raman spectra -- The interaction of light with nanoscopic metal particles and molecules on smooth reflecting surfaces -- Surface enhanced Raman scattering -- Chemical effects and the SERS spectrum -- Is SERS molecule specific? -- SERS/SERRS, the analytical tool -- Surface enhanced infrared spectroscopy. |
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Sommario/riassunto |
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Surface Enhanced Vibrational Spectroscopy (SEVS) has reached maturity as an analytical technique, but until now there has been no single work that describes the theory and experiments of SEVS. This book combines the two important techniques of surface-enhanced Raman scattering (SERS) and surface-enhanced infrared (SEIR) into one text that serves as the definitive resource on SEVS.Discusses both the theory and the applications of SEVS and provides an up-to-date study of the state of the artOffers interpretations of SEVS spectra for practicing analystsDiscusses interpretation of |
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