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Record Nr. |
UNIPARTHENOPE000026533 |
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Titolo |
Criminal justice / edited by Anthea Hucklesby, Azrini Wahidin |
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Pubbl/distr/stampa |
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Oxford : Oxford univ. press, c2009 |
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Titolo uniforme |
Criminal justice |
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ISBN |
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Descrizione fisica |
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Collocazione |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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2. |
Record Nr. |
UNINA9910143411203321 |
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Titolo |
Glycogen synthase kinase 3 (GSK-3) and its inhibitors [[electronic resource] ] : drug discovery and development / / edited by Ana Martinez, Ana Castro, Miguel Medina |
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Pubbl/distr/stampa |
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Hoboken, N.J., : Wiley-Interscience, c2006 |
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ISBN |
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1-280-64906-2 |
9786610649068 |
0-470-05217-1 |
0-470-05215-5 |
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Descrizione fisica |
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1 online resource (388 p.) |
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Collana |
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Wiley series in drug discovery and development |
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Altri autori (Persone) |
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MartínezAna <1961-> |
CastroAna |
MedinaMiguel <1959-> |
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Disciplina |
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Soggetti |
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Glycogen synthase kinase-3 |
Glycogen synthase kinase-3 - Inhibitors |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Glycogen synthase kinase 3: an introductory synopsis -- Glycogen synthase kinase-3[beta] (GSK-3[beta]) a key signaling enzyme: a developmental neurobiological perspective -- Role of GSK-3/Shaggy in neuronal cell biology -- The crystal structures of glycogen synthase kinase 3 -- Kinase-kinase and site-site interactions in the phosphorylation of tau by GSK-3 -- GSK-3, a key player in Alzheimer's disease -- Glycogen synthase kinase 3 : a target for novel mood disorder treatments -- GSK-3 and stem cells -- Glycogen synthase kinase 3 : role in neurodegeneration and neuroprotection -- |
Protein kinase assays for drug discovery -- Animal models with modified expression of GSK-3 for the study of its physiology and of its implications in human pathologies -- Lithium, the seminal GSK-3 inhibitor -- Inhibition of GSK-3 as therapeutic strategy in disease : efficacy of AR-A014418 -- TDZD's: selective and ATP noncompetitive glycogen synthase kinase 3 inhibitors -- 3-amino pyrazoles as potent and selective glycogen kinase synthase (GSK-3) inhibitors -- Marine compounds as a new source for glycogen synthase kinase 3 inhibitors. |
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Sommario/riassunto |
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Many researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3, presents up-to-date information, and mentions the birth of several chemical families of GSK-3 inhibitors with varying selectivity. It's a great reference for researchers in drug design and development. |
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