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Record Nr. |
UNINA9910141821803321 |
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Titolo |
Viral hepatitis [[electronic resource] /] / edited by Howard C. Thomas ... [et al.] |
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Pubbl/distr/stampa |
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Chichester, West Sussex, : John Wiley & Sons, c2014 |
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ISBN |
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1-118-63733-X |
1-118-63727-5 |
1-118-63730-5 |
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Edizione |
[4th ed.] |
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Descrizione fisica |
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1 online resource (642 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Hepatitis, Viral |
Hepatitis |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Cover; Title page; Copyright page; Contents; List of Contributors; Preface; Section I: Introduction to Liver Biology; Chapter 1: Liver regeneration and fibrosis; Introduction; Liver turnover and regeneration; Kinetic organization; Liver regeneration; Molecular regulation of liver regeneration; Stem cells and liver cancer (founders and propagators); Liver fibrosis; References; Chapter 2: Hepatic immunology; Overview of liver immunology; Innate immunity; Cell populations and mediators in the innate immune response; Inflammation in liver diseases; Adaptive immunity; CD4+ T cells; CD8+ T cells |
Regulatory T cellsCD17; B cells; The liver is a unique immune organ; References; Section II: Hepatitis A Virus; Chapter 3: Structure, molecular virology, natural history, and experimental models; Introduction; HAV structure and molecular virology; Genomic structure; Translation, polyprotein processing, and protein function; Particle and antigen structure; Growth in cell culture; Viral receptors and cell entry; Replication and release of viral particles; Genetic diversity; Natural history of HAV; Association of HAV infection with the permanent modulation of immune responses |
Pathogenesis of HAVHAV experimental models; Conclusion; References; Chapter 4: Epidemiology and prevention; Epidemiology; Transmission; |
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Seroprevalence; Molecular epidemiology; Conclusion: epidemiology; Prevention; Active immunization; Passive immunization; Future directions in hepatitis A prevention; Acknowledgment; References; Section III: Hepatitis B Virus and Other Hepadnaviridae; Chapter 5: Structure and molecular virology; HBV morphology, life cycle, and genome organization; Virion morphology: Dane particles; Overview of the HBV life cycle; Genomic structure and organization |
Hepatitis B viral proteinsHBV envelope proteins and HBsAg; Hepatitis B core protein; HBe proteins; Viral polymerase (Pol); The HBx protein; HBV life cycle; Infection study models; Attachment, membrane fusion, and entry; Attachment and infectivity; Formation of cccDNA; Integration of HBV DNA; Regulation of HBV DNA transcription; Translation; Genome replication and regulation; Amplification and stability of cccDNA; Conclusion; References; Chapter 6: Epidemiology and prevention; Epidemiology; Prevalence; Transmission; Infection and its complications; Populations at risk for infection |
Hepatitis B and specific settingsCo-infections; HBV genotypes; Prevention; Primary prevention through immunization; Passive immunization; Active immunization using hepatitis B vaccine; Global vaccination programs; Clinical and epidemiological impact of hepatitis B vaccination; Conclusion; References; Chapter 7: Other Hepadnaviridae (Avihepadnaviridae (DHBV) and Orthohepadnaviridae (WHV)); Hepadnaviridae: Introduction and comparative virology; Avihepadnaviridae: Classification; Avihepadnaviridae: The exogenous replication strategy |
Development of antihepadnaviral agents: The experimental model of DHBV |
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Sommario/riassunto |
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The 4th edition of Viral Hepatitis covers comprehensively the entire complex field of infections caused by all of the different hepatitis viruses, which affect many millions of people throughout the world with considerable morbidity and mortality. Howard Thomas and Arie Zuckerman are joined by Anna Lok from the USA and Stephen Locarnini from Australia as Editors. They have recruited leading researchers and physicians from many countries, who have produced an authoritative account of current knowledge and research on this important infection, including new insights i |
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