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Record Nr. |
UNINA9910141449403321 |
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Autore |
Avdeef Alex |
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Titolo |
Absorption and drug development : solubility, permeability, and charge state / / Alex Avdeef |
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Pubbl/distr/stampa |
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Hoboken, N.J., : John Wiley & Sons, c2012 |
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ISBN |
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9786613619174 |
9781621982265 |
1621982262 |
9781280589348 |
1280589345 |
9781118286036 |
1118286030 |
9781118286067 |
1118286065 |
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Edizione |
[2nd ed.] |
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Descrizione fisica |
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1 online resource (742 p.) |
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Disciplina |
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Soggetti |
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Drugs - Design |
Drugs - Metabolism |
Drug development |
Absorption |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Introduction -- Transport model -- pKa determination -- Octanol-water partitioning -- Liposome-water partitioning -- Solubility -- Permeability - Pampa -- Permeability Caco 2/MDCK -- Permeability blood brain barrier. |
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Sommario/riassunto |
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Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help |
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