1.

Record Nr.

UNINA9910141446103321

Titolo

Protein-ligand interactions / / edited by Holger Gohlke

Pubbl/distr/stampa

Weinheim, : Wiley-VCH, 2012

ISBN

3-527-64596-9

1-280-66289-1

9786613639820

3-527-64594-2

3-527-64597-7

Edizione

[1st ed.]

Descrizione fisica

1 online resource (361 p.)

Collana

Methods and principles in medicinal chemistry ; ; v. 53

Classificazione

CHE 802f

CHE 820f

CHE 825f

540

570

610

WD 5100

Altri autori (Persone)

GohlkeHolger

Disciplina

572.6

572/.6

615.19

Soggetti

Proteins

Ligands (Biochemistry)

Ligand binding (Biochemistry)

Drugs - Structure-activity relationships

Carrier proteins

Ligands

Proteins - pharmacokinetics

Chemistry Techniques, Analytical - methods

Carrier Proteins

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

pt. 1. Binding thermodynamics -- pt. 2. Learning from biophysical



experiments -- pt. 3. Modeling protein-ligand interactions -- pt. 4. Challenges in molecular recognition.

Sommario/riassunto

Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development.The first part provides a basic understanding of the factors governing protein-ligand interaction, followed by a comparison of the four key experimental methods (calorimetry, surface plasmon resonance, NMR and X-ray crystallography) used in generating interaction data. The second half of the book is devoted to in-silico methods of modeling and predicting molecular recognition and binding. Here, as elsewhere in the book, emphasis is place