Immunotherapy in transplantation [[electronic resource] ] : principles and practice / / edited by Bruce Kaplan, Gilbert J. Burckart, Fadi G. Lakkis

• Record Nr.: UNINA9910141335403321
• Pubbl/distr/stampa: West Sussex, : John Wiley, 2012
• ISBN: 1-280-58641-9; 9786613616241; 1-4443-5562-7; 1-4443-5543-0
• Descrizione fisica: 1 online resource (485 p.)
• Altri autori (Persone): KaplanBruce <1958->; BurckartGilbert J; LakkisFadi G
• Disciplina: 615.37
• Soggetti: Immunotherapy; Transplantation immunology
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Immunotherapy in Transplantation: Principles and Practice; Contents; List of Contributors; Preface; Part 1 Transplantation Immunobiology; 1 The Immune Response to a Transplanted Organ: An Overview; 2 Antigen Presentation in Transplantation; 3 The T Cell Response to Transplantation Antigens; 4 The B Cell Response to Transplantation Antigens; 5 The Innate Response to a Transplanted Organ; 6 Regulation of the Alloimmune Response; Part 2 Transplantation Clinical Pharmacology; 7 Pharmacokinetics; 8 Therapeutic Drug Monitoring for Immunosuppressive Agents; 9 Pharmacometrics: Concepts and Applications to Drug Development10 Pharmacogenomics and Organ Transplantation; 11 Study Design/Process of Development: Clinical Studies; Part 3 Agents; 12 Corticosteroids; 13 Azathioprine; 14 Pharmacokinetic and Pharmacodynamic Properties of Mycophenolate; 15 Cyclosporine: Molecular Action to Clinical Therapeutics; 16 Tacrolimus; 17 Inhibitors of Mammalian Target of Rapamycin; 18 Inhibitors Targeting JAK3; 19 ; Cyclophosphamide; 20 Application of Antisense Technology in Medicine; 21 The Role of Ganciclovir in Transplantation; 22 Transplantation Immunotherapy with Antithymocyte Globulin (ATG)23 The Role of Alemtuzumab in Solid Organ Transplantation; 24 Rituximab, an Anti-CD20 Monoclonal Antibody; 25 The Anti-Interleukin 2 Receptor Antibodies; 26 Infliximab/Anti-TNF; 27 CTLA4-Ig; 28 Combination and Adjuvant Therapies to Facilitate the Efficacy of Costimulatory Blockade; 29 Intravenous Immunoglobulin (IVIG) a Modulator of Immunity and Inflammation with Applications in Solid Organ Transplantation; Index; Color Plates
• Sommario/riassunto: This comprehensive reference source will benefit all transplant specialists working with pharmacologic and biologic agents that modulate the immune system. Compiled by a team of world-renowned editors and contributors covering the fields of transplantation, nephrology, pharmacology, and immunology, the book covers all anti-rejection drugs according to a set template and includes the efficacy of each for specific diseases.