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Record Nr. |
UNINA9910140832103321 |
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Titolo |
Aggregation of therapeutic proteins [[electronic resource] /] / edited by Wei Wang, Christopher J. Roberts |
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Pubbl/distr/stampa |
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Hoboken, NJ, : Wiley, c2010 |
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ISBN |
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1-118-04358-8 |
1-282-70798-1 |
9786612707988 |
0-470-76982-3 |
0-470-76981-5 |
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Descrizione fisica |
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1 online resource (514 p.) |
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Altri autori (Persone) |
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WangWei <1957 Mar. 10-> |
RobertsChristopher John <1972-> |
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Disciplina |
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Soggetti |
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Protein drugs |
Aggregation (Chemistry) |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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AGGREGATION OF THERAPEUTIC PROTEINS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1: Fundamental Structures and Behaviors of Proteins; CHAPTER 2: Protein Aggregation Pathways, Kinetics, and Thermodynamics; CHAPTER 3: Identification and Impact of Aggregation-Prone Regions in Proteins and Therapeutic Monoclonal Antibodies; CHAPTER 4: External Factors Affecting Protein Aggregation; CHAPTER 5: Experimental Detection and Characterization of Protein Aggregates; CHAPTER 6: Approaches to Control Protein Aggregation during Bulk Production |
CHAPTER 7: Protein Aggregation and Particle Formation: Effects of Formulation, Interfaces, and Drug Product Manufacturing OperationsCHAPTER 8: Approaches to Managing Protein Aggregation in Product Development; CHAPTER 9: Case Studies Involving Protein Aggregation; CHAPTER 10: Aggregation and Immunogenicity of Therapeutic Proteins; CHAPTER 11: Regulatory Perspective on Aggregates as a Product Quality Attribute; INDEX; color plate |
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Sommario/riassunto |
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This book gives pharmaceutical scientists an up-to-date resource on |
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