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1. |
Record Nr. |
UNINA9910459722103321 |
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Titolo |
Iron-sulfur clusters in chemistry and biology / / edited by Tracey Rouault |
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Pubbl/distr/stampa |
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Berlin, [Germany] ; ; Boston, [Massachusetts] : , : De Gruyter, , 2014 |
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©2014 |
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ISBN |
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1-5231-0058-3 |
3-11-037826-4 |
3-11-030842-8 |
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Descrizione fisica |
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1 online resource (672 p.) |
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Classificazione |
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Disciplina |
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Soggetti |
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Iron-sulfur proteins |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Front matter -- Preface -- Tracey A. Rouault biography -- Contents -- Contributing authors -- 1. Iron-sulfur proteins: a historical perspective / Bonomi, Francesco / Rouault, Tracey A. -- 2. Chemistry of iron-sulfur clusters / Ichiye, Toshiko -- 3. Quantitative interpretation of EPR spectroscopy with applications for iron-sulfur proteins / Petasis, Doros T. / Hendrich, Michael P. -- 4. The utility of Mössbauer spectroscopy in eukaryotic cell biology and animal physiology / Chakrabarti, Mrinmoy / Lindahl, Paul A. -- 5. The interstitial carbide of the nitrogenase M-cluster: insertion pathway and possible function / Hu, Yilin / Ribbe, Markus -- 6. The iron-molybdenum cofactor of nitrogenase / Spatzal, Thomas / Andrade, Susana L. A. / Einsle, Oliver -- 7. Biotin synthase: a role for iron-sulfur clusters in the radical-mediated generation of carbon-sulfur bonds / Jarrett, Joseph T. -- 8. Molybdenum-containing iron-sulfur enzymes / Hille, Russ -- 9. The role of iron-sulfur clusters in the biosynthesis of the lipoyl cofactor / Lanz, Nicholas D. / Booker, Squire J. -- 10. Iron-sulfur clusters and molecular oxygen: function, adaptation, degradation, and repair / Nicolet, Yvain / Fontecilla-Camps, Juan C. -- 11. A retrospective on the discovery of [Fe-S] cluster biosynthetic machineries in Azotobacter vinelandii / Dos Santos, |
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Patricia C. / Dean, Dennis R. -- 12. A stress-responsive Fe-S cluster biogenesis system in bacteria - the suf operon of Gammaproteobacteria / Outten, F. Wayne -- 13. Sensing the cellular Fe-S cluster demand: a structural, functional, and phylogenetic overview of Escherichia coli IscR / Mettert, Erin L. / Perna, Nicole T. / Kiley, Patricia J. -- 14. Fe-S assembly in Gram-positive bacteria / Dos Santos, Patricia C. -- 15. Fe-S cluster assembly and regulation in yeast / Pain, Debkumar / Dancis, Andrew -- 16. The role of Fe-S clusters in regulation of yeast iron homeostasis / Outten, Caryn E. -- 17. Biogenesis of Fe-S proteins in mammals / Rouault, Tracey A. -- 18. Iron-sulfur proteins and human diseases / Tong, Wing-Hang -- 19. Connecting the biosynthesis of the molybdenum cofactor, Fe-S clusters, and tRNA thiolation in humans / Leimkühler, Silke -- 20. Iron-sulfur proteins and genome stability / Gari, Kerstin -- 21. Eukaryotic iron-sulfur protein biogenesis and its role in maintaining genomic integrity / Lill, Roland / Uzarska, Marta A. / Wohlschlegel, James -- 22. Iron-sulfur cluster assembly in plants / Ye, Hong -- 23. Origin and evolution of Fe-S proteins and enzymes / Boyd, Eric S. / Schut, Gerrit J. / Shepard, Eric M. / Broderick, Joan B. / Adams, Michael W. W. / Peters, John W. -- Index |
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Sommario/riassunto |
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This volume on iron-sulfur proteins includes chapters that describe the initial discovery of iron-sulfur proteins in the 1960's to elucidation of the roles of iron sulfur clusters as prosthetic groups of enzymes, such as the citric acid cycle enzyme, aconitase, and numerous other proteins, ranging from nitrogenase to DNA repair proteins. The capacity of iron sulfur clusters to accept and delocalize single electrons is explained by basic chemical principles, which illustrate why iron sulfur proteins are uniquely suitable for electron transport and other activities. Techniques used for detection and stabilization of iron-sulfur clusters, including EPR and Mossbauer spectroscopies, are discussed because they are important for characterizing unrecognized and elusive iron sulfur proteins. Recent insights into how nitrogenase works have arisen from multiple advances, described here, including studies of high-resolution crystal structures. Numerous chapters discuss how microbes, plants, and animals synthesize these complex prosthetic groups, and why it is important to understand the chemistry and biogenesis of iron sulfur proteins. In addition to their vital importance in mitochondrial respiration, numerous iron sulfur proteins are important in maintenance of DNA integrity. Multiple rare human diseases with different clinical presentations are caused by mutations of genes in the iron sulfur cluster biogenesis pathway. Understanding iron sulfur proteins is important for understanding a rapidly expanding group of metabolic pathways important in all kingdoms of life, and for understanding processes ranging from nitrogen fixation to human disease. |
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2. |
Record Nr. |
UNINA9910140803903321 |
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Titolo |
Alternatives to blood transfusion in transfusion medicine [[electronic resource] /] / edited by Alice Maniatis, Philippe van der Linden, Jean-François Hardy |
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Pubbl/distr/stampa |
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Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley, 2010 |
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ISBN |
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1-4443-4766-7 |
1-282-77452-2 |
9786612774522 |
1-4443-1958-2 |
1-4443-1653-2 |
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Edizione |
[2nd ed.] |
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Descrizione fisica |
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1 online resource (608 p.) |
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Altri autori (Persone) |
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ManiatisAlice |
LindenPhilippe van der |
HardyJean-François |
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Disciplina |
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Soggetti |
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Blood - Transfusion |
Blood - Transfusion - Complications |
Blood substitutes - Therapeutic use |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Rev. ed. of: Transfusion medicine and alternatives to blood transfusion / NATA (Network for Advancement of Transfusion Alternatives). c2000. |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Alternatives to Blood Transfusion in Transfusion Medicine; Contents; Contributors List; Part 1 History and Development of Transfusion Medicine; 1 From Blood Transfusion to Transfusion Medicine; Part 2 Allogeneic Blood Usage-Risks and Benefits; 2 Allogeneic Blood Components; 3 Current Information on the Infectious Risks of Allogeneic Blood Transfusion; 4 Immunological Complications of Blood Transfusion; 5 Immunomodulation and Allogeneic Blood Transfusion; 6 Pathogen Inactivation of Blood Components; 7 The Benefits of Allogeneic Erythrocyte Transfusion: What Evidence Do We Have? |
Part 3 Volume Replacement Section 1 Plasma and Albumin; Section 2 Crystalloids and Synthetic Colloids; Part 4 Tolerance of Anemia; 17 Basic Principles of Oxygen Transport and Calculations; 18 Assessment of Tissue Oxygenation; 19 Tissue Oxygenation and Blood Transfusion; |
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20 Anemia and Cardiovascular Disease; Part 5 Perioperative Hemostasis; 21 Monitoring of Hemostasis in the Perioperative Setting; 22 Antifibrinolytics in Open-Heart Surgery; 23 Efficacy and Safety of Recombinant Activated Factor VII to Control Bleeding in Nonhemophiliac Patients; Part 6 Transfusion Triggers |
24 Role of Hemoglobin/Hematocrit 25 Calculation of Blood Loss; 26 Management of Massive Transfusion; Part 7 Alternatives to Allogeneic Blood Transfusion; Section 1 Pharmaceutical Approaches; Section 2 Surgical Techniques; Section 3 Anesthetic Techniques; Section 4 Special Settings; Part 8 Legal and Ethical Issues in Transfusion Medicine; 43 Ethical Aspects of Informed Consent: American Models; 44 Blood Transfusions, Jehovah's Witnesses, and the American Patients' Rights Movement; Part 9 Cost Issues; 45 The Cost and Cost-Effectiveness of Allogeneic and Autologous Blood |
46 Autologous Blood Predonation in Cardiac Surgery 47 Cost-Effectiveness of Pharmacological Alternatives; Index |
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Sommario/riassunto |
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Meeting the needs of patients while minimizing blood transfusions requires special expertise, precise monitoring and innovative techniques. This cutting-edge resource covers all the important clinical aspects of transfusion medicine in diverse clinical settings, with a special emphasis on alternatives to transfusion. Edited by a multidisciplinary team consisting of a transfusion specialist, an anesthesiologist and an intensive care specialist this book is endorsed by the Network for Advancement of Transfusion Alternatives. The contributors review the appropriate use of fluids and of blood pr |
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