Cardiotoxicity of non-cardiovascular drugs [[electronic resource] /] / editor, Giorgio Minotti

• Record Nr.: UNINA9910140586903321
• Pubbl/distr/stampa: Chichester, West Sussex, : Wiley, 2010
• ISBN: 1-282-54804-2; 9786612548048; 0-470-66037-6; 0-470-66038-4
• Descrizione fisica: 1 online resource (362 p.)
• Altri autori (Persone): MinottiGiorgio
• Disciplina: 616.1/061
• Soggetti: Cardiovascular toxicology
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Machine generated contents note: List of Contributors -- 1. Mitochondrial Dysfunction In Cell Injury and Cardiotoxicity -- Fabio Di Lisa, Martina Semenzato, Andrea Carpi, Sara Menazza, Nina Kaludercic, Roberta Menabò, Marcella Canton -- 2. Cardiovascular Liabilities of Drugs: Regulatory Aspects -- Claudio Arrigoni -- 3. Cellular Mechanisms, Molecular Targets, and Structure-Function Relationships In Drug-Induced Arrhythmias: The Case Of Antihistamines, Psychoactive Drugs, and Antimicrobial Agents -- Maria Virginia Soldovieri and Maurizio Taglialatela -- 4. Cardiovascular Toxicity of Antitumor Drugs: Dimensions of the Problem in Children -- Rebecca Scully, Louis Pruitt, Steven E. Lipshultz -- 5. Cardiovascular Toxicity of Antitumor Drugs: Dimension of the Problem in Adult Settings -- Joseph R. Carver and Chaitali J. Desai -- 6. Diagnostic Aspects of Cardiovascular Toxicity of Antitumor Drugs -- Michael S. Ewer, Thomas M. Suter -- 7. Cardiovascular Toxicity of Antitumor Drugs: Translating Molecular Mechanisms into Clinical Facts -- Pierantonio Menna, Emanuela Salvatorelli, Carlo Salsano, Luca Gianni*, and Giorgio Minotti -- 8. NSAID Action and the Foundations for Cardiovascular Toxicity -- Anna L. Blobaum and Lawrence J. Marnett -- 9. Cardiovascular toxicities of NSAIDS: Epidemiologic aspects -- Antonio González-Pe;rez, Luis Alberto Garci;a Rodriguez -- 10. Cardiovascular Toxicities of ; Life-Saving Drugs: Antiviral Therapy -- James J. Kohler & William Lewis.
• Sommario/riassunto: "First book to deal with this important area of adverse drug reactions -- cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals. Covers four important therapeutic classes: psychoactive drugs; anticancer drugs; non-steroidal anti-inflammatory drugs; and anti-retroviral drugs. - Emphasis on the preclinical screening of drug cardiotoxicity, to enable drug developers to test for this toxicity before starting expensive clinical trials"--Provided by publisher.

Development of Sustainable Energy : Generation Technologies and Concepts

• Record Nr.: UNINA9910673906403321
• Autore: Muneer Tariq
• Pubbl/distr/stampa: Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020
• Descrizione fisica: 1 online resource (130 p.)
• Soggetti: Research & information: general
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Sommario/riassunto: The book begins with an investigation of improved diesel generator flexibility and coordination via low-load diesel applications. Case studies for Australia and Hawaii are presented to conclude that low-load diesel is a natural precursor to storage due to its accessibility and also benefits low and high-penetration isolated power systems. The book continues with Structural Equation Modelling of building occupants attitude, knowledge and behaviour to propose the inclusion of motivational factors in a Building Occupant Environmental Behaviour model for sustainable building energy performance. The following section presents an analysis of different levels of renewable energy integration and energy storage to suggest the most suitable in terms of ; the reduction of CO2 emissions and expected earnings from a lower LCOE. Further on, a proof-of-concept heat pipe technology for passive cooling to improve the performance of photovoltaic panels in the hot climate of Oman is presented using computational fluid dynamics (CFD). The application of an uncontrolled diode rectifier-high voltage direct current transmission system for the Jeju Island power system with an off-shore new wind farm is simulated to demonstrate cost reduction and increased reliability and stability. The book concludes with view factor computations of bifacial solar photovoltaic based on the finite element method using two programming languages to demonstrate that Python offers a better platform than Microsoft Excel-Visual Basic for Applications where computation time is a significant modelling challenge.