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Record Nr. |
UNINA9910140484103321 |
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Titolo |
The chemistry of molecular imaging / / edited by Nicholas Long, Wing-Tak Wong |
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Pubbl/distr/stampa |
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Hoboken, New Jersey : , : Wiley, , [2015] |
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©2015 |
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ISBN |
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1-118-85481-0 |
1-118-85475-6 |
1-118-85477-2 |
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Descrizione fisica |
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1 online resource (434 p.) |
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Classificazione |
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Disciplina |
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Soggetti |
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Imaging systems |
Imaging systems in medicine |
Molecular probes |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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The Chemistry of Molecular Imaging; Copyright; Contents; Preface; List of Contributors; Chapter 1 An Introduction to Molecular Imaging; 1.1 Introduction; 1.2 What is Positron Emission Tomography (PET)?; 1.2.1 Basic Principles; 1.2.2 Advantages and Limitations; 1.3 What is Single Photon Emission Computed Tomography (SPECT)?; 1.3.1 Basic Principles; 1.3.2 Advantages and Limitations; 1.4 What is Computed Tomography (CT) or Computed Axial Tomography (CAT)?; 1.4.1 Basic Principles; 1.4.2 Advantages and Limitations; 1.5 What is Magnetic Resonance Imaging (MRI)?; 1.5.1 Basic Principles |
1.5.2 Advantages and Limitations1.6 What is Optical Imaging?; 1.6.1 Basic Principles; 1.6.2 Conventional or Wide-Field Fluorescence Microscopy; 1.6.3 Confocal Microscopy or Confocal Laser Scanning Microscopy; 1.6.4 Advantages and Limitations; 1.7 What is Ultrasound (US)?; 1.7.1 Basic Principles; 1.7.2 Advantages and Limitations; 1.8 Conclusions; References; Chapter 2 Chemical Methodology for Labelling and Bioconjugation; 2.1 Introduction; 2.2 Chemical Methods; 2.2.1 Through Reactions with Aldehydes or Ketones; 2.2.2 Through |
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Reactions with Azides; 2.2.3 Through Reactions with Alkenes |
2.2.4 Cross-Coupling Reactions2.3 Site-Specific Modification of Proteins or Peptides; 2.3.1 N-terminal Cysteine; 2.3.2 Aromatic Residues; 2.3.3 N-terminus of Protein; 2.3.4 C-terminus of Protein; 2.3.5 Introduction of Chemical Tags for Site-Specific Labelling on Peptides or Proteins; 2.4 Conclusions; References; Chapter 3 Recent Developments in the Chemistry of [18F]Fluoride for PET; 3.1 Introduction; 3.2 Fluorine-18: The Starting Material; 3.3 Reactive [18F]Fluoride; 3.4 The Radiofluorination; 3.4.1 Electrophilic Reactions; 3.4.2 Nucleophilic Reactions |
3.5 Labelling of Large Biological Molecules3.5.1 The Prosthetic Group Concept; 3.5.2 Prosthetic Entities with Fluorine-18 Bound to Aluminium, Boron, or Silicon; 3.5.3 Click Chemistry; 3.6 Conclusions; References; Chapter 4 Carbon-11, Nitrogen-13, and Oxygen-15 Chemistry: An Introduction to Chemistry with Short-Lived Radioisotopes; 4.1 Introduction; 4.2 Carbon-11 Chemistry; 4.2.1 Synthesis with [11C]Carbon Dioxide; 4.2.2 [11C]methylation Reactions; 4.2.3 [11C]Phosgene Reactions; 4.2.4 [11C]Cyanation Reactions; 4.2.5 [11C]Carbonylation Reactions; 4.3 Nitrogen-13 Chemistry |
4.3.1 Synthesis of 13N-labelled Amines4.3.2 Enzymatic Synthesis of 13N-labelled Amino Acid; 4.3.3 Synthesis of [13N]cisplatin; 4.3.4 Synthesis of [13N] Carbamates and Ureas; 4.3.5 Other 13N-labelling Reactions; 4.4 Oxygen-15 Chemistry; 4.5 Conclusions; References; Chapter 5 The Chemistry of Inorganic Nuclides (86Y, 68Ga, 64Cu, 89Zr, 124I); 5.1 Introduction: Inorganic Nuclide-Based Radiopharmaceuticals; 5.2 Radiopharmaceutical Design; 5.3 Radiopharmaceutical Stability; 5.4 86Yttrium Radiometal Ion Properties; 5.4.1 Clinical Trials Based on 86Yttrium; 5.4.2 Recent 86Yttrium Work |
5.4.3 Stability of 86Yttrium-Based Radiopharmaceuticals |
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Sommario/riassunto |
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"Covering all the fundamentals of modern imaging methodologies, including their techniques and application within medicine and industry, The Chemistry of Molecular Engineering focuses primarily on the chemistry of probes and imaging agents, as well as chemical methodology for labelling and bioconjugation. Written by an interdisciplinary team of experts, this book investigates the chemistry of molecular imaging and helps to educate non-chemists already involved in the area of molecular imaging. It addresses all the major modalities and techniques, such as MRI, positron emission tomography, single photon emission computed tomography, ultrasound, and fluorescence/optical imaging"-- |
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