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Record Nr. |
UNINA9910462572903321 |
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Titolo |
Bacterial toxins : genetics, cellular biology and practical applications / / Edited by Thomas Proft |
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Pubbl/distr/stampa |
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Norfolk, England : , : Caister Academic Press, , [2013] |
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©2013 |
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ISBN |
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Descrizione fisica |
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1 online resource (249 p.) |
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Disciplina |
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Soggetti |
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Bacterial toxins |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Table of Contents; Chapter 1. Receptor-related Risk Factors for Verotoxin Pathogenesis; Verotoxins and their receptors; Receptor glycolipid; B subunit receptor-binding sites; VT signalling and internalization; Cholesterol masking of VT receptors; New model for VTB subunit pentamer binding plasma membrane Gb3; Cholesterol is key for VT-Gb3 retrograde transport; Regulation of Gb3 biosynthesis; Soluble GSL mimics; Conclusions; References; Chapter 2. The Helicobacter pylori CagA Protein: A Multifunctional BacterialToxin Delivered by Type IV Secretion; Introduction |
The cag pathogenicity island and its effector protein CagAThe Cag type IV secretion system as a toxin delivery system; CagA interaction partners and associated effects in host cells; Conclusions; Chapter 3. Pore-forming Toxins; Introduction; Introduction to Staphylococcus aureus α-haemolysin; Nomenclature and early observations; Primary structure and regulation of toxin production; Three-dimensional structure and function; Role in disease pathogenesis; Summary and future perspectives - α-toxin |
Introduction to the cholesterol-dependent cytolysins and membrane attack complex/perforin (MACPF) family proteinsGeneral features of the CDC primary structure; The CDC monomer crystal structure; Secretion of the CDCs; Cellular recognition; The CDC membrane anchoring system; The CDC allosteric pathway; Formation of the prepore |
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oligomer; Formation of the pore complex; Ring versus arc oligomers; The CDCs and bacterial pathogenesis; The membrane attack complex/perforin (MACPF) proteins; Summary and futureperspectives - CDCs andMACPF proteins; References |
Chapter 4. Bacterial Enterotoxins as Immunomodulators and Vaccine AdjuvantsIntroduction; Cholera toxin: the prototype for ADP-ribosylating holotoxin adjuvants; LT: a more complex family of holotoxin adjuvants; Are ADP-ribosylating toxins in general good adjuvants?; Taking toxin adjuvant immunomodulation one step further; Concluding remarks; References; Chapter 5. Mobile Genetic Elements as Carriers for Bacterial Virulence Genes; Core and adaptive genome; The mobile bacterial genome; Mobile genetic elements and their role in virulence; Why MGEs encode exotoxins and other virulence factors? |
Role of SOS inductionBacteriophage-encoding toxins and other virulence factors; Plasmids encoding toxins; Pathogenicity islands encoding toxins; Open questions; Web resources; References; Chapter 6. The Staphylococcal Superantigen-like Toxins; Introduction; The SSLs - an introduction; Genetics of the ssls; Molecular biology of the SSLs; SSL-related S. aureus immune evasion molecules; Mechanisms of immune evasion mediated by SSLs; Novel SSL-associated applications; Concluding remarks; References; Chapter 7. Botulinum Neurotoxins as Therapeutics; Introduction |
Mechanistic basis of BoNTs as therapeutics |
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Sommario/riassunto |
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Toxins are virulence determinants that play an important role in microbial pathogenicity and/or evasion of the host immune response. This makes them ideal targets for the development of novel antimicrobial strategies. The potential applications of toxin research extend beyond simply combating microbial pathogens, and include use as novel anti-cancer drugs and other front-line medicines and as tools in neurobiology. In the field of cellular biology, toxins have become invaluable as tools for the manipulation and investigation of fundamental cellular and physiological processes. Research in this |
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2. |
Record Nr. |
UNINA9910139977603321 |
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Autore |
Dorsey Jason R (Jason Ryan) |
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Titolo |
Y-size your business : how Gen Y employees can save you money and grow your business / / Jason Ryan Dorsey |
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Pubbl/distr/stampa |
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Hoboken, New Jersey : , : Wiley, , 2010 |
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©2010 |
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ISBN |
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0-470-58337-1 |
1-282-38031-1 |
9786612380310 |
1-118-27180-7 |
0-470-58295-2 |
0-470-58336-3 |
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Descrizione fisica |
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1 online resource (242 p.) |
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Disciplina |
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Soggetti |
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Personnel management |
Young adults - Employment |
Generation Y |
Employee motivation |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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Y-Size Your Business: How Gen Y Employees Can Save You Money and Grow Your Business; CONTENTS; Chapter 1: Hiring Gen Y Makes Dollars and Sense; Chapter 2: Behind the Scenes (and Screen Names) with Gen Y; Chapter 3: Four Generations, One Workplace, Lots of Issues; Chapter 4: An Overview on How to Y-Size Your Business; Chapter 5: What Gen Y Really Looks for in a Job; Chapter 6: Attract Quality Gen Y Employees Faster than Free Pizza at 2 AM; Chapter 7: Day One Is All-Important; Chapter 8: Orientation: Confirming Our Fit within Your Culture; Chapter 9: Keep Gen Y Engaged @ Work |
Chapter 10: Develop Gen Y Talent by Making "Good Enough" |
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UnacceptableChapter 11: Professionalism Is More than Bling; Chapter 12: Motivate Gen Y by NOT Giving Us a Trophy; Chapter 13: Retain Gen Y-and Our Enthusiasm; Chapter 14: Lead Me to Loyalty; Chapter 15: Build a Talent Pipeline Like; A CALL TO ACTION: WHY REACH OUT TO GEN Y-YOUR LEGACY AND OPPORTUNITY; ACKNOWLEDGMENTS; ABOUT THE AUTHOR; INDEX |
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Sommario/riassunto |
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In today's economy, maximizing the performance of every employee is critical to business survival and growth. Gen Y-sometimes called Millennials-provides an enticing opportunity for employers to increase their short-term profitability and create a long-term competitive advantage. Almost 80 million strong, Gen Y is the fastest growing segment in the US workforce-and now comprises the entire 18 to 32 demographic. Along with their ever-present cell phone and occasional backpack, Gen Y brings tremendous potential and timely skills to the workplace (just ask, they'll tell you). However, Gen Y can b |
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