|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910139730203321 |
|
|
Titolo |
Management of chemical and biological samples for screening applications / / edited by Mark Wigglesworth and Terry Wood |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Weinheim, : Wiley-VCH, c2012 |
|
|
|
|
|
|
|
ISBN |
|
3-527-64526-8 |
1-283-43214-5 |
9786613432148 |
3-527-64525-X |
|
|
|
|
|
|
|
|
Edizione |
[1st ed.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (434 p.) |
|
|
|
|
|
|
Altri autori (Persone) |
|
WigglesworthMark |
WoodTerry, Dr. |
|
|
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Pharmaceutical technology |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Management of Chemical and Biological Samples for Screening Applications; Contents; Preface; List of Contributors; 1 Introduction to Sample Management; References; 2 Generating a High-Quality Compound Collection; 2.1 Defining Current Screening Collections; 2.2 Design Criteria for Enriching a Compound Collection with Drug-Like Compounds; 2.2.1 Physicochemical Tailoring of a Compound Collection; 2.2.2 Lipophilicity Design Considerations; 2.2.3 Other Physicochemical Roadblocks; 2.2.4 Assessing Risk - from Rule of 5 to Rule of 3/75; 2.2.5 Tools Enabling Desk Top In Silico Design |
2.3 Concluding RemarksReferences; 3 Assessing Compound Quality; 3.1 Introduction; 3.2 Process Quality and Analytical Quality in Compound Management; 3.2.1 Process Quality (QA); 3.2.2 Analytical Quality (Sample QC); 3.3 Identity; 3.4 Purity/Stability; 3.4.1 Measuring Purity; 3.4.2 Determining the Most Appropriate Purity Cut-Off for Solutions; 3.4.3 Stability of Solutions; 3.5 Concentration/Solubility; 3.6 Conclusions; Acknowledgments; References; Further Reading; 4 Delivering and Maintaining Quality within Compound Management; 4.1 Introduction |
4.2 What is Quality from a Compound Management Perspective?4.3 |
|
|
|
|