1.

Record Nr.

UNINA9910139614103321

Titolo

Current and Future Issues in Hemophilia Care / / edited by Emérito-Carlos Rodríguez-Merchán, Leonard A. Valentino

Pubbl/distr/stampa

Hoboken, : Wiley, 2011

ISBN

1-283-20458-4

9786613204585

1-119-97940-4

1-119-97937-4

Descrizione fisica

1 online resource (190 p.)

Disciplina

600

616.1572

Soggetti

Blood Coagulation Factors

Hemophilia

Hemorrhagic Disorders

Blood Coagulation Disorders, Inherited

Biological Factors

Coagulation Protein Disorders

Blood Proteins

Blood Coagulation Disorders

Proteins

Genetic Diseases, Inborn

Hematologic Diseases

Hemic and Lymphatic Diseases

Amino Acids, Peptides, and Proteins

Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Diseases

Hemophilia A

Medicine

Health & Biological Sciences

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.



Nota di contenuto

Current and Future Issues in Hemophilia Care; Contents; List of Contributors; Preface; Part 1: Introduction; 1 History of Hemophilia; 2 Hemophilia Care in the Modern World; 3 Comprehensive Care Model in Hemophilia; Part 2: General Topics; 4 When Should We Switch from On-Demand to Prophylaxis Regimen?; 5 Prophylaxis in Children; 6 Prophylaxis in Adults with Hemophilia; 7 The Economics of Prophylaxis: Does Prophylaxis with Clotting Factor Represent Value for Money?; 8 The Transition of Care for the Young Adult Hemophilia Patient; 9 Perinatal Clinical Care and Molecular Diagnosis in Hemophilia

10 Managing the Mature Person with Hemophilia11 Quality of Life in Hemophilia; Part 3: Inhibitors; 12 Immunology of Inhibitor Development; 13 Epidemiology of Inhibitors; 14 Early Tolerization to Minimize Inhibitors in PUPs with Hemophilia A; 15 Prediction of Inhibitors in Severe Hemophilia; 16 Genetic Basis for Inhibitor Development; 17 Non-Genetic Risk Factors for Inhibitor Development; Part 4: Inhibitor Treatment; 18 Immune Tolerance Induction Programs; 19 Prophylaxis in Hemophilia A Patients with Inhibitors; 20 Treatment of Bleeding in FVIII Inhibitor Patients

21 Discordancy of Bypassing Therapy Part 5: Joint Health and Disease; 22 Experimental Studies on Hemarthrosis, Synovitis and Arthropathy; 23 Assessment of Joint Involvement in Hemophilia; 24 Imaging of the Hemophilic Joint; 25 Initial and Advanced Stages of Hemophilic Arthropathy, and Other Musculo-Skeletal Problems: The Role of Orthopedic Surgery; 26 Perioperative Thromboprophylaxis for Persons with Hemophilia Undergoing Orthopedic Surgery; Part 6: New Developments; 27 New Technologies for the Pharmacokinetic Improvement of Coagulation Factor Proteins

28 Current and Future Approaches to Gene Therapy in Patients with Hemophilia29 New Developments in Hemophilic Arthropathy; 30 Physiotherapy Evaluation and Intervention in the Acute Hemarthrosis: Challenging the Paradigm; 31 Laboratory Assays to Predict Response to Bypassing Agents; 32 Combination/Sequential Use of Bypassing Agents; Index

Sommario/riassunto

As haemophilia is a life-long condition, continuing supervision by a group of medical personnel is required. In many countries this is provided by comprehensive care haemophilia centres where staff of all specialities concerned with treatment- haematologists, paediatricians, nurses, physiotherapists, orthopaedic surgeons - have specialized knowledge. This new book is a definitive resource on the current aspects and issues around haemophilia. Complications of haemophilia care are well covered in chapters on inhibitors, and musculoskeletal problems, as are all the latest developments in the