1.

Record Nr.

UNINA9910139591503321

Autore

McCaughan Geoffrey W

Titolo

Advanced Therapy for Hepatitis C [[electronic resource]]

Pubbl/distr/stampa

Hoboken, : Wiley, 2011

ISBN

1-283-28323-9

9786613283238

1-4443-4634-2

1-4443-4631-8

Descrizione fisica

1 online resource (233 p.)

Altri autori (Persone)

McHutchisonJohn

PawlotskyJean-Michel

Disciplina

616.3/62306

616.362306

Soggetti

Antiviral agents

Antiviral Agents - therapeutic use

Antiviral Agents -- therapeutic use

Hepatitis C - therapy

Hepatitis C -- therapy

Hepatitis C - Treatment

Hepatitis C -- Treatment

Hepatitis, Viral, Human

Flaviviridae Infections

Anti-Infective Agents

RNA Virus Infections

Therapeutic Uses

Virus Diseases

Hepatitis

Diseases

Liver Diseases

Pharmacologic Actions

Chemical Actions and Uses

Digestive System Diseases

Antiviral Agents

Hepatitis C

Medicine

Health & Biological Sciences

Gastroenterology



Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di contenuto

Advanced Therapy for Hepatitis C; Contents; Contributors; Preface; Section I Foundations for Understanding Antiviral Therapies in HCV; 1 HCV Replication; 2 Hepatitis C Virus Genotypes; 3 Immune Responses to HCV: Implications for Therapy; 4 Mechanisms of Action of Antiviral Drugs: The Interferons; 5 Pharmacology and Mechanisms of Action of Antiviral Drugs: Ribavirin Analogs; 6 Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors; 7 Pharmacology and Mechanisms of Action of Antiviral Drugs: Protease Inhibitors; 8 Measuring Antiviral Responses

Section II Efficacy and Clinical Use of Antiviral Therapies9 Genotype 1: Standard Treatment; 10 Individually Tailored Treatment Strategies in Treatment-naìˆve Chronic Hepatitis C Genotype 1 Patients; 11 Genotype 1 Relapsers and Non-responders; 12 Standard Therapy for Genotypes 2/3; 13 Altered Dosage or Durations of Current Antiviral Therapy for HCV Genotypes 2 and 3; 14 Genotypes 2 and 3 Relapse and Non-response; 15 Hepatitis C Genotype 4 Therapy: Progress and Challenges; 16 Antivirals in Acute Hepatitis C; 17 Antivirals in Cirrhosis and Portal Hypertension

18 Treatment of Recurrent Hepatitis C Following Liver Transplantation19 Antiviral Treatment in Chronic Hepatitis C Virus Infection with Extrahepatic Manifestations; 20 Cytopenias: How they Limit Therapy and Potential Correction; 21 The Problem of Insulin Resistance and its Effect on Therapy; 22 HIV and Hepatitis C Co-infection; 23 HCV and Racial Differences; 24 HCV and the Pediatric Population; 25 New Horizons: IL28, Direct-acting Antiviral Therapy for HCV; Index

Sommario/riassunto

Hepatologists, both researchers and front-line clinicians, now have a comprehensive guide to the treatment of patients with the HCV virus. This book focuses mainly on the efficacy and clinical use of antiviral therapies, including the use of antivirals post liver transplantation and in the presence of the HIV virus. It also explores the foundations for understanding antiviral therapies in HCV, such as the complex pharmacology and mechanisms of antiviral drugs. A 'late-breaking information' chapter contains the most recent trial results on the latest antiviral drugs.